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Table 4 Alcohol intake and gout association results in genotype-stratified groups in people of Polynesian ancestry for GCKR

From: Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout

 

No alcohol intake (n = 1007)

Any alcohol intake (n = 732)

 

Adjusted OR (95% CI)

P value

Adjusted OR (95% CI)

P value

P Difference

All

T-

1

1

1.73 (1.21–2.46)

0.002

 
 

T+

1.92 (1.41–2.62)

3.18 × 10−5

2.07 (1.47–2.92)

2.91 × 10−5

0.25

Beer

T−

1

1

1.60 (1.10–2.32)

0.013

 
 

T+

1.70 (1.28–2.25)

2 × 10−4

2.17 (1.50–3.13)

3.79 × 10−5

0.13

Nonbeer

T−

1

1

1.68 (1.09–2.59)

0.020

 
 

T+

1.78 (1.37–2.32)

1.95 × 10−5

1.81 (1.22–2.67)

0.003

0.66

  1. Associations are adjusted for age, sex, body mass index, STRUCTURE ancestry estimates, and ancestry class (Western vs. Eastern Polynesian vs. mixed Western/Eastern Polynesians). P Difference is that between genotype groups in the alcohol-exposed subset