Fig. 2
From: Genetic deficiency of Wnt5a diminishes disease severity in a murine model of rheumatoid arthritis
Whole body inducible Wnt5a knockout (Wnt5a cKO) mice develop less severe rheumatoid arthritis (RA) based upon histological analyses. a H&E-stained sections from the ankles in control and Wnt5a cKO mice at day 7 after induction of arthritis demonstrate hallmark features of the disease at the tarsotibial joint (top panels) and the tarsonavicular joint (bottom panels), including expanded pannus formation (arrowheads) and destruction pits (arrow). b Qualitative metrics of the damage induced by RA in control and Wnt5a cKO mice demonstrates reduced overall disease severity (H&E score), clinical score, cartilage destruction, inflammation, polymononuclear (PMN) cell infiltration and extra-articular lesions in the joints of Wnt5a cKO mice. *P ≤ 0.05