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Table 2 Biomarker levels at baseline

From: Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study

 

Chondroitin sulfate (n = 57)

Celecoxib (n = 62)

P value*

CRP, μg/mL†

4.02 ± 5.41 (n = 48)

5.56 ± 5.54 (n = 46)

0.042

HA, ng/mL

62.46 ± 44.81

72.46 ± 60.45

0.267

Leptin, ng/mL

37.60 ± 43.78

44.23 ± 38.53

0.214

Adipsin, μg/mL

4.05 ± 1.07

4.19 ± 1.07

0.638

MMP-1, ng/mL

5.11 ± 4.13

4.69 ± 3.15

0.827

MMP-3, ng/mL

13.03 ± 6.31

13.85 ± 11.04

0.720

PIIANP, μg/mL

4.10 ± 1.92

4.10 ± 1.61

0.468

CTX-1, ng/mL

0.59 ± 0.18

0.53 ± 0.12

0.035

  1. Data shown are mean ± SD. CRP C reactive protein, HA hyaluronic acid, MMP matrix metalloproteinase, PIIANP N-terminal propeptide of collagen IIα, CTX-1 C-terminal crosslinked telopeptide of type I collagen. *Mann-Whitney test; p values in italics are statistically significant. †Data missing for 25 patients at baseline
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Arthritis Research & Therapy

ISSN: 1478-6362

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