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Table 2 Biomarker levels at baseline

From: Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study

  Chondroitin sulfate (n = 57) Celecoxib (n = 62) P value*
CRP, μg/mL 4.02 ± 5.41 (n = 48) 5.56 ± 5.54 (n = 46) 0.042
HA, ng/mL 62.46 ± 44.81 72.46 ± 60.45 0.267
Leptin, ng/mL 37.60 ± 43.78 44.23 ± 38.53 0.214
Adipsin, μg/mL 4.05 ± 1.07 4.19 ± 1.07 0.638
MMP-1, ng/mL 5.11 ± 4.13 4.69 ± 3.15 0.827
MMP-3, ng/mL 13.03 ± 6.31 13.85 ± 11.04 0.720
PIIANP, μg/mL 4.10 ± 1.92 4.10 ± 1.61 0.468
CTX-1, ng/mL 0.59 ± 0.18 0.53 ± 0.12 0.035
  1. Data shown are mean ± SD. CRP C reactive protein, HA hyaluronic acid, MMP matrix metalloproteinase, PIIANP N-terminal propeptide of collagen IIα, CTX-1 C-terminal crosslinked telopeptide of type I collagen. *Mann-Whitney test; p values in italics are statistically significant. Data missing for 25 patients at baseline