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Table 3 Correlations between the biomarker levels at baseline in all subjects

From: Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study

   CRP (n = 94*) HA (n = 119) Leptin (n = 119) Adipsin (n = 119) MMP-1 (n = 119) MMP-3 (n = 119) PIIANP (n = 119) CTX-1 (n = 117**)
CRP r - - - - - - - -
  p value - - - - - - - -
HA r <0.0001 - - - - - - -
  p value >0.999 - - - - - - -
Leptin r 0.344 -0.006 - - - - - -
  p value 0.001 0.947 - - - - - -
Adipsin r -0.016 0.188 0.343 - - - - -
  p value 0.881 0.040 0.001 - - - - -
MMP-1 r 0.045 -0.009 0.036 0.234 - - - -
  p value 0.664 0.922 0.702 0.010 - - - -
MMP-3 r 0.051 0.195 -0.245 0.049 -0.064 - - -
  p value 0.627 0.033 0.007 0.594 0.489 - - -
PIIANP r 0.025 -0.042 0.015 -0.059 -0.277 -0.070 - -
  p value 0.813 0.650 0.875 0.524 0.002 0.451 - -
CTX-1 r -0.093 0.063 0.016 -0.105 -0.049 -0.099 0.075 -
  p value 0.380 0.497 0.862 0.262 0.601 0.287 0.422 -
  1. CRP C reactive protein, HA hyaluronic acid, MMP matrix metalloproteinase, PIIANP N-terminal propeptide of collagen IIα, CTX-1 C-terminal crosslinked telopeptide of type I collagen. *Data missing for 25 patients at baseline; **data missing for 2 patients at baseline
  2. Pearson’s correlation; p values in italics are statistically significant