Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study

Table 3 Correlations between the biomarker levels at baseline in all subjects

		CRP (n = 94*)	HA (n = 119)	Leptin (n = 119)	Adipsin (n = 119)	MMP-1 (n = 119)	MMP-3 (n = 119)	PIIANP (n = 119)	CTX-1 (n = 117**)
CRP	r	-	-	-	-	-	-	-	-
	p value^†	-	-	-	-	-	-	-	-
HA	r	<0.0001	-	-	-	-	-	-	-
	p value	>0.999	-	-	-	-	-	-	-
Leptin	r	0.344	-0.006	-	-	-	-	-	-
	p value	0.001	0.947	-	-	-	-	-	-
Adipsin	r	-0.016	0.188	0.343	-	-	-	-	-
	p value	0.881	0.040	0.001	-	-	-	-	-
MMP-1	r	0.045	-0.009	0.036	0.234	-	-	-	-
	p value	0.664	0.922	0.702	0.010	-	-	-	-
MMP-3	r	0.051	0.195	-0.245	0.049	-0.064	-	-	-
	p value	0.627	0.033	0.007	0.594	0.489	-	-	-
PIIANP	r	0.025	-0.042	0.015	-0.059	-0.277	-0.070	-	-
	p value	0.813	0.650	0.875	0.524	0.002	0.451	-	-
CTX-1	r	-0.093	0.063	0.016	-0.105	-0.049	-0.099	0.075	-
	p value	0.380	0.497	0.862	0.262	0.601	0.287	0.422	-

CRP C reactive protein, HA hyaluronic acid, MMP matrix metalloproteinase, PIIANP N-terminal propeptide of collagen IIα, CTX-1 C-terminal crosslinked telopeptide of type I collagen. *Data missing for 25 patients at baseline; **data missing for 2 patients at baseline
^†Pearson’s correlation; p values in italics are statistically significant

ISSN: 1478-6362