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Table 4 Associations between cartilage volume and its loss and biomarker levels at baseline for all subjects

From: Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study

   CRP (n = 94*) HA (n = 119) Leptin (n = 119) Adipsin (n = 119) MMP-1 (n = 119) MMP-3 (n = 119) PIIANP (n = 119) CTX-1 (n = 117**)
Cartilage volume at baseline
Medial compartment β -49.24 -1.66 -4.26 101.26 -2.49 9.35 -40.65 -773.37
  p value 0.045 0.409 0.385 0.315 0.931 0.454 0.489 0.256
Medial condyle β -37.09 -0.75 -2.62 74.50 -1.99 7.41 -38.66 -407.44
  p value 0.030 0.591 0.441 0.287 0.920 0.392 0.342 0.389
Medial plateau β -12.15 -0.91 -1.63 26.77 -0.50 1.94 -1.99 -365.94
  p value 0.170 0.215 0.361 0.468 0.962 0.671 0.926 0.141
Cartilage volume loss at 2 years
Medial compartment β -0.179 0.001 0.009 0.334 0.049 -0.022 -0.546 3.418
  p value 0.029 0.905 0.590 0.342 0.622 0.615 0.007 0.150
Medial condyle β -0.184 0.004 -0.012 0.275 0.137 -0.038 -0.606 2.792
  p value 0.050 0.643 0.560 0.501 0.235 0.455 0.010 0.313
Medial plateau β -0.164 -0.005 0.049 0.415 -0.100 -0.001 -0.420 4.532
  p value 0.102 0.512 0.016 0.321 0.402 0.989 0.083 0.106
  1. CRP C reactive protein, HA hyaluronic acid, MMP matrix metalloproteinase, PIIANP N-terminal propeptide of collagen IIα, CTX-1 C-terminal crosslinked telopeptide of type I collagen, β regression parameter estimate of the biomarker. *Data missing for 25 patients at baseline; **data missing for 2 patients at baseline. Linear regression adjusted for age, gender and body mass index; p values in italics are statistically significant