Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study

Table 4 Associations between cartilage volume and its loss and biomarker levels at baseline for all subjects

		CRP (n = 94*)	HA (n = 119)	Leptin (n = 119)	Adipsin (n = 119)	MMP-1 (n = 119)	MMP-3 (n = 119)	PIIANP (n = 119)	CTX-1 (n = 117**)
Cartilage volume at baseline
Medial compartment	β	-49.24	-1.66	-4.26	101.26	-2.49	9.35	-40.65	-773.37
	p value^†	0.045	0.409	0.385	0.315	0.931	0.454	0.489	0.256
Medial condyle	β	-37.09	-0.75	-2.62	74.50	-1.99	7.41	-38.66	-407.44
	p value	0.030	0.591	0.441	0.287	0.920	0.392	0.342	0.389
Medial plateau	β	-12.15	-0.91	-1.63	26.77	-0.50	1.94	-1.99	-365.94
	p value	0.170	0.215	0.361	0.468	0.962	0.671	0.926	0.141
Cartilage volume loss at 2 years
Medial compartment	β	-0.179	0.001	0.009	0.334	0.049	-0.022	-0.546	3.418
	p value	0.029	0.905	0.590	0.342	0.622	0.615	0.007	0.150
Medial condyle	β	-0.184	0.004	-0.012	0.275	0.137	-0.038	-0.606	2.792
	p value	0.050	0.643	0.560	0.501	0.235	0.455	0.010	0.313
Medial plateau	β	-0.164	-0.005	0.049	0.415	-0.100	-0.001	-0.420	4.532
	p value	0.102	0.512	0.016	0.321	0.402	0.989	0.083	0.106

CRP C reactive protein, HA hyaluronic acid, MMP matrix metalloproteinase, PIIANP N-terminal propeptide of collagen IIα, CTX-1 C-terminal crosslinked telopeptide of type I collagen, β regression parameter estimate of the biomarker. *Data missing for 25 patients at baseline; **data missing for 2 patients at baseline. ^†Linear regression adjusted for age, gender and body mass index; p values in italics are statistically significant

ISSN: 1478-6362