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Table 5 Two-year medial region cartilage volume loss (%) according to median value of baseline biomarker levels per treatment group

From: Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study

 

Lower than median

Higher than median

Chondroitin Sulfate

Celecoxib

P value†

Chondroitin Sulfate

Celecoxib

P value†

CRPa (n = 94)* Median 3.2 μg/mL

      

n

28

19

 

20

27

 

Medial compartment

-6.00 ± 3.31

-7.40 ± 3.81

0.237

-7.21 ± 3.49

-8.63 ± 4.65

0.510

Medial condyle

-5.13 ± 4.05

-6.99 ± 4.46

0.188

-6.05 ± 4.22

-8.28 ± 4.90

0.211

Medial plateau

-7.40 ± 3.90

-7.91 ± 4.49

0.745

-9.10 ± 5.12

-9.14 ± 5.56

0.642

HAa (n = 119) Median 50.2 ng/mL

      

n

31

28

 

34

26

 

Medial compartment

-5.85 ± 3.24

-8.90 ± 3.95

0.083

-7.45 ± 3.11

-8.10 ± 4.46

0.629

Medial condyle

-4.99 ± 4.03

-8.57 ± 4.79

0.047

-6.61 ± 3.89

-7.73 ± 4.74

0.334

Medial clateau

-7.12 ± 3.74

-9.32 ± 4.32

0.275

-8.98 ± 4.50

-8.71 ± 5.33

0.671

LEPTINb (n = 119) Median 24.9 ng/ml

      

n

30

30

 

27

32

 

Medial compartment

-6.58 ± 3.12

-9.42 ± 4.50

0.011

-6.58 ± 3.45

-7.61 ± 3.89

0.445

Medial condyle

-5.90 ± 3.93

-9.16 ± 5.40

0.014

-5.54 ± 4.17

-7.16 ± 3.99

0.227

Medial plateau

-7.64 ± 3.08

-9.90 ± 4.90

0.037

-8.34 ± 5.17

-8.20 ± 4.85

0.846

ADIPSINb (n = 119) Median 4.1 μg/mL

      

n

31

29

 

26

33

 

Medial compartment

-6.48 ± 3.06

-8.76 ± 4.40

0.040

-6.70 ± 3.53

-8.20 ± 4.11

0.161

Medial condyle

-5.16 ± 3.83

-8.38 ± 4.97

0.007

-6.42 ± 4.19

-7.88 ± 4.60

0.249

Medial plateau

-8.64 ± 4.14

-9.35 ± 5.21

0.701

-7.16 ± 4.15

-8.67 ± 4.61

0.190

MMP-1c (n = 119) Median 3.6 ng/mL

      

n

25

34

 

32

28

 

Medial compartment

-7.12 ± 3.38

-8.44 ± 3.68

0.239

-6.16 ± 3.14

-8.49 ± 4.86

0.050

Medial condyle

-6.29 ± 4.47

-8.20 ± 4.41

0.165

-5.30 ± 3.63

-8.01 ± 5.20

0.028

Medial plateau

-8.53 ± 3.48

-8.77 ± 4.46

0.908

-7.53 ± 4.65

-9.26 ± 5.40

0.269

MMP-3c (n = 119) Median 11.2 ng/mL

      

n

27

32

 

30

30

 

Medial compartment

-7.10 ± 3.26

-7.29 ± 4.26

0.945

-6.12 ± 3.23

-9.72 ± 3.86

0.001

Medial condyle

-6.39 ± 3.81

-6.94 ± 4.45

0.765

-5.15 ± 4.16

-9.37 ± 4.79

0.001

Medial plateau

-8.21 ± 4.53

-7.67 ± 5.04

0.736

-7.75 ± 3.89

-10.40 ± 4.34

0.048

PIIANPd (n = 119) Median 3.9 μg/mL

      

n

28

31

 

29

31

 

Medial compartment

-5.59 ± 2.96

-7.45 ± 4.02

0.115

-7.54 ± 3.28

-9.48 ± 4.23

0.070

Medial condyle

-4.91 ± 4.00

-6.97 ± 4.43

0.164

-6.52 ± 3.93

-9.25 ± 4.84

0.026

Medial plateau

-6.52 ± 3.23

-8.27 ± 5.04

0.129

-9.37 ± 4.54

-9.71 ± 4.67

0.829

CTX-1d (n = 117)** Median 0.53 ng/mL

      

n

23

35

 

33

26

 

Medial compartment

-7.11 ± 3.46

-8.83 ± 4.14

0.170

-6.15 ± 3.13

-7.83 ± 4.37

0.085

Medial condyle

-6.43 ± 4.08

-8.38 ± 4.65

0.186

-5.20 ± 4.01

-7.67 ± 5.00

0.025

Medial plateau

-8.03 ± 4.14

-9.56 ± 4.78

0.237

-7.87 ± 4.29

-7.99 ± 4.89

0.931

  1. Data are cartilage volume loss (%) expressed as mean ± SD. CRP C reactive protein, HA hyaluronic acid, MMP matrix metalloproteinase, PIIANP N-terminal propeptide of collagen IIα, CTX-1 C-terminal crosslinked telopeptide of type I collagen. Biomarkers related to ainflammation; badipokines; cmatrix metalloproteinases; dcollagen metabolism. †Analysis of covariance adjusted for age, gender, body mass index and, for HA only, cartilage volume at baseline; p values in italics are statistically significant. *Data missing for 25 patients at baseline; **data missing for 2 patients at baseline
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Arthritis Research & Therapy

ISSN: 1478-6362

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