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Table 5 Two-year medial region cartilage volume loss (%) according to median value of baseline biomarker levels per treatment group

From: Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study

  Lower than median Higher than median
Chondroitin Sulfate Celecoxib P value Chondroitin Sulfate Celecoxib P value
CRPa (n = 94)* Median 3.2 μg/mL       
n 28 19   20 27  
Medial compartment -6.00 ± 3.31 -7.40 ± 3.81 0.237 -7.21 ± 3.49 -8.63 ± 4.65 0.510
Medial condyle -5.13 ± 4.05 -6.99 ± 4.46 0.188 -6.05 ± 4.22 -8.28 ± 4.90 0.211
Medial plateau -7.40 ± 3.90 -7.91 ± 4.49 0.745 -9.10 ± 5.12 -9.14 ± 5.56 0.642
HAa (n = 119) Median 50.2 ng/mL       
n 31 28   34 26  
Medial compartment -5.85 ± 3.24 -8.90 ± 3.95 0.083 -7.45 ± 3.11 -8.10 ± 4.46 0.629
Medial condyle -4.99 ± 4.03 -8.57 ± 4.79 0.047 -6.61 ± 3.89 -7.73 ± 4.74 0.334
Medial clateau -7.12 ± 3.74 -9.32 ± 4.32 0.275 -8.98 ± 4.50 -8.71 ± 5.33 0.671
LEPTINb (n = 119) Median 24.9 ng/ml       
n 30 30   27 32  
Medial compartment -6.58 ± 3.12 -9.42 ± 4.50 0.011 -6.58 ± 3.45 -7.61 ± 3.89 0.445
Medial condyle -5.90 ± 3.93 -9.16 ± 5.40 0.014 -5.54 ± 4.17 -7.16 ± 3.99 0.227
Medial plateau -7.64 ± 3.08 -9.90 ± 4.90 0.037 -8.34 ± 5.17 -8.20 ± 4.85 0.846
ADIPSINb (n = 119) Median 4.1 μg/mL       
n 31 29   26 33  
Medial compartment -6.48 ± 3.06 -8.76 ± 4.40 0.040 -6.70 ± 3.53 -8.20 ± 4.11 0.161
Medial condyle -5.16 ± 3.83 -8.38 ± 4.97 0.007 -6.42 ± 4.19 -7.88 ± 4.60 0.249
Medial plateau -8.64 ± 4.14 -9.35 ± 5.21 0.701 -7.16 ± 4.15 -8.67 ± 4.61 0.190
MMP-1c (n = 119) Median 3.6 ng/mL       
n 25 34   32 28  
Medial compartment -7.12 ± 3.38 -8.44 ± 3.68 0.239 -6.16 ± 3.14 -8.49 ± 4.86 0.050
Medial condyle -6.29 ± 4.47 -8.20 ± 4.41 0.165 -5.30 ± 3.63 -8.01 ± 5.20 0.028
Medial plateau -8.53 ± 3.48 -8.77 ± 4.46 0.908 -7.53 ± 4.65 -9.26 ± 5.40 0.269
MMP-3c (n = 119) Median 11.2 ng/mL       
n 27 32   30 30  
Medial compartment -7.10 ± 3.26 -7.29 ± 4.26 0.945 -6.12 ± 3.23 -9.72 ± 3.86 0.001
Medial condyle -6.39 ± 3.81 -6.94 ± 4.45 0.765 -5.15 ± 4.16 -9.37 ± 4.79 0.001
Medial plateau -8.21 ± 4.53 -7.67 ± 5.04 0.736 -7.75 ± 3.89 -10.40 ± 4.34 0.048
PIIANPd (n = 119) Median 3.9 μg/mL       
n 28 31   29 31  
Medial compartment -5.59 ± 2.96 -7.45 ± 4.02 0.115 -7.54 ± 3.28 -9.48 ± 4.23 0.070
Medial condyle -4.91 ± 4.00 -6.97 ± 4.43 0.164 -6.52 ± 3.93 -9.25 ± 4.84 0.026
Medial plateau -6.52 ± 3.23 -8.27 ± 5.04 0.129 -9.37 ± 4.54 -9.71 ± 4.67 0.829
CTX-1d (n = 117)** Median 0.53 ng/mL       
n 23 35   33 26  
Medial compartment -7.11 ± 3.46 -8.83 ± 4.14 0.170 -6.15 ± 3.13 -7.83 ± 4.37 0.085
Medial condyle -6.43 ± 4.08 -8.38 ± 4.65 0.186 -5.20 ± 4.01 -7.67 ± 5.00 0.025
Medial plateau -8.03 ± 4.14 -9.56 ± 4.78 0.237 -7.87 ± 4.29 -7.99 ± 4.89 0.931
  1. Data are cartilage volume loss (%) expressed as mean ± SD. CRP C reactive protein, HA hyaluronic acid, MMP matrix metalloproteinase, PIIANP N-terminal propeptide of collagen IIα, CTX-1 C-terminal crosslinked telopeptide of type I collagen. Biomarkers related to ainflammation; badipokines; cmatrix metalloproteinases; dcollagen metabolism. Analysis of covariance adjusted for age, gender, body mass index and, for HA only, cartilage volume at baseline; p values in italics are statistically significant. *Data missing for 25 patients at baseline; **data missing for 2 patients at baseline