Fig. 6
From: Inhibition of T cell-mediated inflammation in uveitis by a novel anti-CD3 antibody
Suppression of Th1 and Th17 cells in Dow2-treated uveitis models. Representative images are shown for immunohistochemistry of retinal sections in experimental autoimmune uveitis (EAU) (Dow2 or rat IgG isotype control). Fluorescence images stained for (a) IFN-γ (green), CD4 (red), and with DAPI (blue), and (b) IL-17 (green), CD4 (red), and with DAPI (blue); n = 3 eyes per group. Scale bar = 20 μm. (c) Splenocytes were collected from Dow2- or rat IgG-treated EAU mice to detect Th1/Th17 cells after administration of these Abs. Percentages indicate double-positive CD4+IFN-γ+ or CD4+IL-17+ cells (n = 3 per group)