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Table 2 Presence of perifascicular atrophy and RIG-I staining in the muscle biopsies of patients with DM and non-DM (1) and sensitivity and specificity of atrophy and RIG-I positivity to diagnose DM (2)

From: RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis

1)
  PFA#, a PFA (2 rows)b RIG-Ic    
 DM (N; %) 16 (36%) 11 (25%) 22 (50%)    
 No DM (N; %) 13 (21%) 5 (8%) 7 (11%)    
 p* 0.09 0.02 <0.001    
2)
     p (a vs b)** p (a vs c)** p (b vs c)**
 Sensitivity 36% 25% 50% 0.06 0.08 0.005
 Specificity 79% 92% 88% <0.01 0.08 0.7
 Reproducibility (κ)***   0.37 0.51    
  1. Healthy controls were excluded from this analysis. DM dermatomyositis, PFA perifascicular atrophy. #Perifascicular atrophy includes one or more rows of atrophic muscle fibers. *Association between bivariate variables was perfomed using Fisher’s exact test. **Sensitivity and specificity were compared using the McNemar test. ***Reproducibility was assessed using Cohen’s kappa coefficient (κ).