TY - JOUR AU - Li, Pei AU - Hou, Gang AU - Zhang, Ruijie AU - Gan, Yibo AU - Xu, Yuan AU - Song, Lei AU - Zhou, Qiang PY - 2017 DA - 2017/09/18 TI - High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway JO - Arthritis Research & Therapy SP - 209 VL - 19 IS - 1 AB - Mechanical overloading can lead to disc degeneration. Nucleus pulposus (NP) cell senescence is aggravated within the degenerated disc. This study was designed to investigate the effects of high compression on NP cell senescence and the underlying molecular mechanism of this process. SN - 1478-6362 UR - https://doi.org/10.1186/s13075-017-1384-z DO - 10.1186/s13075-017-1384-z ID - Li2017 ER -