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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway

Fig. 3

Analysis of SA-β-Gal activity, telomerase activity, G1 cell cycle arrest and senescence marker (p16 and p53) expression in the nucleus pulposus (NP) cells from scaffold culture. 20% deformation compression significantly increased SA-β-Gal activity (a), decreased telomerase activity (b), promoted G1 cell cycle arrest (c) and upregulated senescence markers expression (d). The addition of the ROS scavenger NAC attenuated these effects caused by 20% deformation compression. Scale = 100 μm. Data are expressed as the mean ± SD (n = 3). *Indicates a significant difference (p < 0.05) between two groups; #indicates a significant difference (p < 0.05) compared with the control group

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