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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway

Fig. 4

Gene expression of matrix macromolecules (aggrecan and collagen II) and glycosaminoglycan (GAG) content from nucleus pulposus (NP) cells in scaffold culture. 20% deformation compression significantly downregulated gene expression of matrix molecules (a) and decreased GAG content (b), which could be partly reversed by treatment with the ROS scavenger NAC. Data are expressed as the mean ± SD (n = 3). *Indicates a significant difference (p < 0.05) between two groups; #indicates a significant difference (p < 0.05) compared with the control group

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