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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway

Fig. 6

Effects of p38 MAPK inhibition on reactive oxygen species (ROS generation and the cell proliferation of nucleus pulposus (NP) cells in the 20% deformation compression group. The specific inhibitor SB203580 significantly inhibited p38 MAPK pathway activation (a). Inhibition of the p38 MAPK pathway decreased ROS generation (b) and suppressed the proliferation potency (c) of NP cells in the 20% deformation compression group. Data are expressed as the mean ± SD (n = 3). *Indicates a significant difference (p < 0.05) between the two groups. RFU relative fluorescence units

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