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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren’s syndrome patients and correlates with focus score and disease activity

Fig. 4

IHC evaluation of autophagy expression in minor salivary gland biopsies of patients with primary Sjögren’s syndrome (pSS) and nonspecific chronic sialoadenitis (nSS). ac Representative photomicrographs showing 3-μm thick paraffin-embedded sections of lip gland biopsy specimens obtained from nSS (a) and patients with pSS (b, c), stained for LC3-II. d Correlation of LC3-II with FS. LC3-II expression in infiltrating cells by IHC was correlated with the FS of pSS. eg. Representative photomicrographs showing 3-μm thick paraffin-embedded sections of lip gland biopsy specimens obtained from nSS (e) and patients with pSS (f, g), stained for Atg5. h. Atg5 expression in infiltrating cells by IHC was correlated with the FS of pSS. jl. p62/SQSTM1 immunoreactivity in lip gland biopsies of nSS (j, k) and pSS patients (l). m Number of p62/SQSTM1 cells in pSS and nSS. (ac, eg, original magnification × 250; jl original magnification × 400)

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