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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren’s syndrome patients and correlates with focus score and disease activity

Fig. 5

IIF on pSS salivary glands with inflammatory infiltrates evaluating LC3-II and Atg5 tissue expression in relation to CD4+ T cells. a–c. Representative image of LC3-II/Atg5 immunostainings of lip gland biopsies of pSS patients: single staining for LC3-II (green) (a) and Atg5 (red) (b), and merged double staining for LC3-II and Atg5 (c). df. Immunolocalization by confocal microscopy of CD4 (green) and Atg5 (red) in pSS salivary gland biopsies. g–i. Immunolocalization by confocal microscopy of CD8 (green) and Atg5 (red) in pSS salivary gland biopsies. l–n. Immunolocalization by confocal microscopy of CD4 (green) and LC3-II (red) in pSS salivary gland biopsies. oq. Immunolocalization by confocal microscopy of CD8 (green) and LC3-II (red) in pSS salivary gland biopsies. Significant colocalization of Atg5 with CD4 (f) but not CD8 (i), and significant colocalization of LC3-II with CD4 (o) but not CD8 (q) was detected in the inflamed glands of pSS. (aq, original magnification × 250)

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