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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Endoplasmic reticulum stress cooperates with Toll-like receptor ligation in driving activation of rheumatoid arthritis fibroblast-like synoviocytes

Fig. 3

Synergism between ER stress and multiple TLR ligands. mRNA expression of IL6 (a), IL8 (b), and CXCL10 (c) in RA FLS was measured by qPCR after 4-h stimulation with the indicated TLR ligands in the presence or absence of 10 nM TG. d IL-6 and IL-8 protein production in response to combined treatment with LPS and TG was measured by ELISA. * p < 0.05; ** p < 0.01; *** p < 0.001. CXCL Chemokine (C-X-C motif) ligand, ELISA Enzyme-linked immunosorbent assay, ER Endoplasmic reticulum, FLS Fibroblast-like synoviocytes, GAPDH Glyceraldehyde 3-phosphate dehydrogenase, IL Interleukin, LPS Lipopolysaccharide, mRNA Messenger RNA, pIC Polyinosinic:polycytidylic acid, qPCR Quantitative polymerase chain reaction, RA Rheumatoid arthritis, TG Thapsigargin, TLR Toll-like receptor

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