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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis

Fig. 2

Regulation of LOXL2 gene expression by osteoarthritis (OA)-related mediators: Human articular OA chondrocytes (HAC-OA) were treated with TNF-α, IL-1β, or transforming growth factor-β1 (TGF-β1) at 10 or 30 ng/mL for 24 h, and LOXL2 mRNA levels were assessed by RTqPCR. Data are represented as mean ± SEM of three independent experiments with 95% confidence interval (CI) (*P < 0.001; Student’s t test). LOXL2 gene expression was significantly upregulated by TGF-β1 (P < 0.001) and downregulated by TNF-α (P < 0.001) and IL-1β (P < 0.001).

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