Fig. 4
From: IgG Fc galactosylation predicts response to methotrexate in early rheumatoid arthritis
The log[FA2/(FA2G1 + FA2G2)] value of immunoglobulin G1 (IgG1) as a predictive factor for response. a Good (GR) and moderate responders (MR) compared with patients with no response (NR) to methotrexate treatment. Patients are split into seropositive (Pos) and seronegative (Neg) groups. Cutoff −0.045. b ROC curve for distinguishing the responding and nonresponding patient cohorts. c ROC curve for distinguishing the responding and nonresponding patient cohorts when only seropositive patients were included. Following false discovery rate correction, p = 0.001 remains significant. FA2 Main agalactosylated, FA2G1 Main monogalactosylated Fc glycan, FA2G2 Main digalactosylated Fc, NS Not significant