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Table 1 Characteristics and of patients and healthy control subjects

From: IgG Fc galactosylation predicts response to methotrexate in early rheumatoid arthritis

 

Healthy control subjects (n = 11)

Early RA

All patients (n = 59)

GR (n = 19)

MR (n = 20)

NR (n = 20)

p Valuea

Age, years

54 (45–57)

53 (45–62)

49 (41–63)

49 (41–56)

55 (49–65)

0.03

Female sex

73%

72%

68%

65%

80%

0.28

Current smoking

10%

34%

31%

30%

30%

0.52

ACPA- and/or RF-positive

–

75%

74%

75%

75%

0.96

DAS28-ESR

–

5.7 (5.0–6.2)

5.2 (5.0–6.0)

6.0 (5.4–6.4)

5.2 (4.7–6.4)

0.40

HAQ

–

1.3 (0.9–1.6)

1.1 (0.8–1.4)

1.4 (1.0–1.9)

1.3 (0.9–1.6)

0.66

DAS28-ESR follow-up

–

4.5 (2.6–5.1)

2.2 (1.7–2.6)

4.4 (4.0–4.9)

5.4 (4.9–5.8)

<0.0001

MTX duration, weeks

–

14 (13–15)

14 (13–15)

14 (13–15)

14 (14–15)

0.50

Prednisolone

–

25%

31%

30%

15%

0.19

  1. Abbreviations: ACPA Anticitrullinated protein antibodies, DAS28-ESR Disease Activity Score in 28 joints based on erythrocyte sedimentation rate, GR Good response, HAQ Health Assessment Questionnaire, MR Moderate response, MTX Methotrexate, NR No response, RA Rheumatoid arthritis, RF Rheumatoid factor
  2. All characteristics are from assessments at baseline, except when otherwise stated. Values are of the median (first to third quartiles), except when otherwise indicated. Response was categorized according to European League Against Rheumatism response criteria
  3. aComparison of patients not responding (no European League Against Rheumatism [EULAR] response) and patients responding (EULAR good or moderate response)