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Table 2 Baseline characteristics of study participants

From: Safety, tolerability, clinical, and joint structural outcomes of a single intra-articular injection of allogeneic mesenchymal precursor cells in patients following anterior cruciate ligament reconstruction: a controlled double-blind randomised trial

 

MPC + HA (n = 11)

HA alone (n = 6)

p*

Age, years

26.0 (3.6)

26.9 (10.3)

0.85

Females, number (%)

3 (27)

2 (33)

0.79

Body mass index, kg/m2

25.1 (3.1)

25.1 (4.6)

1.00

Interval between ACL injury and reconstruction, days

76.5 (54.3)

61.7 (34.8)

0.56

Interval between ACL reconstruction and intra-articular injection, days

48.5 (14.0)

47.8 (8.3)

0.92

KOOS

 Pain

69.1 (11.7)

84.2 (11.9)

0.02

 Symptoms

59.7 (10.8)

83.9 (11.7)

<0.001

 Activities of daily living

82.1 (11.0)

92.8 (6.4)

0.047

 Sport and recreation function

29.7 (17.6)

40.0 (14.1)

0.47

 Knee-related quality of life

40.9 (19.8)

50.0 (16.8)

0.36

SF-36 physical component score

41.3 (4.7)

45.9 (5.8)

0.11

 Physical functioning

41.0 (6.2)

43.7 (1.7)

0.31

 Role limitation: physical

40.0 (7.0)

42.6 (8.1)

0.51

 Bodily pain

42.3 (8.6)

53.5 (5.4)

0.01

 General health perception

55.2 (6.6)

55.4 (7.9)

0.95

Joint space width, mm

 Medial tibiofemoral compartment

4.36 (0.55)

4.97 (0.63)

0.06

 Lateral tibiofemoral compartment

5.38 (0.62)

5.67 (0.52)

0.36

Knee structure measured from MRI

 Medial tibial cartilage volume, mm3

2456 (397)

2627 (476)

0.44

 Lateral tibial cartilage volume, mm3

3291 (401)

3548 (847)

0.51

 Medial tibial plateau bone area, mm2

2299 (337)

2187 (182)

0.46

 Lateral tibial plateau bone area, mm2

1472 (202)

1415 (193)

0.58

  1. Data are reported as mean (SD) or number (%)
  2. *For difference between two groups using independent samples t test or chi-squared test where appropriate
  3. ACL anterior cruciate ligament, KOOS Knee Injury and Osteoarthritis Outcome Score, MRI magnetic resonance imaging