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Table 2 Baseline characteristics of study participants

From: Safety, tolerability, clinical, and joint structural outcomes of a single intra-articular injection of allogeneic mesenchymal precursor cells in patients following anterior cruciate ligament reconstruction: a controlled double-blind randomised trial

  MPC + HA (n = 11) HA alone (n = 6) p*
Age, years 26.0 (3.6) 26.9 (10.3) 0.85
Females, number (%) 3 (27) 2 (33) 0.79
Body mass index, kg/m2 25.1 (3.1) 25.1 (4.6) 1.00
Interval between ACL injury and reconstruction, days 76.5 (54.3) 61.7 (34.8) 0.56
Interval between ACL reconstruction and intra-articular injection, days 48.5 (14.0) 47.8 (8.3) 0.92
KOOS
 Pain 69.1 (11.7) 84.2 (11.9) 0.02
 Symptoms 59.7 (10.8) 83.9 (11.7) <0.001
 Activities of daily living 82.1 (11.0) 92.8 (6.4) 0.047
 Sport and recreation function 29.7 (17.6) 40.0 (14.1) 0.47
 Knee-related quality of life 40.9 (19.8) 50.0 (16.8) 0.36
SF-36 physical component score 41.3 (4.7) 45.9 (5.8) 0.11
 Physical functioning 41.0 (6.2) 43.7 (1.7) 0.31
 Role limitation: physical 40.0 (7.0) 42.6 (8.1) 0.51
 Bodily pain 42.3 (8.6) 53.5 (5.4) 0.01
 General health perception 55.2 (6.6) 55.4 (7.9) 0.95
Joint space width, mm
 Medial tibiofemoral compartment 4.36 (0.55) 4.97 (0.63) 0.06
 Lateral tibiofemoral compartment 5.38 (0.62) 5.67 (0.52) 0.36
Knee structure measured from MRI
 Medial tibial cartilage volume, mm3 2456 (397) 2627 (476) 0.44
 Lateral tibial cartilage volume, mm3 3291 (401) 3548 (847) 0.51
 Medial tibial plateau bone area, mm2 2299 (337) 2187 (182) 0.46
 Lateral tibial plateau bone area, mm2 1472 (202) 1415 (193) 0.58
  1. Data are reported as mean (SD) or number (%)
  2. *For difference between two groups using independent samples t test or chi-squared test where appropriate
  3. ACL anterior cruciate ligament, KOOS Knee Injury and Osteoarthritis Outcome Score, MRI magnetic resonance imaging