Fig. 4

Anti-CarP IgG1 is associated with more severe radiological progression. The extent and rate of joint destruction was analysed in all rheumatoid arthritis (RA) patients or separately for anti-citrullinated protein antibody (ACPA)-negative and ACPA-positive RA and within the ACPA-negative RA patients also separately for rheumatoid factor (RF) negative and positive. The severity of joint damage is depicted as median Sharp-van der Heijde score (SHS) on the y axis and the follow-up years on the x axis for anti-carbamylated protein (anti-CarP) antibody immunoglobulin (Ig)G1-positive and -negative patients in all RA patients analysed (a) and for ACPA- and RF-negative RA patients (b). β and p values are derived from the analysis model as described in the Methods and Results sections