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Table 3 Associations of anti-carbamylated protein antibody isotypes and IgG subclasses with baseline characteristics

From: The isotype and IgG subclass distribution of anti-carbamylated protein antibodies in rheumatoid arthritis patients

Isotypes

IgG– (n = 190)

IgG + (n = 182)

p

IgA– (n = 221)

IgA + (n = 152)

p

IgM– (n = 312)

IgM + (n = 61)

p

 

ESR, mm/h

  

0.676

  

0.157

  

0.216

 

Mean ± SD Median (IQR)

41.2 ± 25.3 37.0 (33.3)

42.9 ± 26.8 37.0 (44.5)

40.4 ± 25.7 34.5 (33.0)

44.2 ± 26.4 39.0 (43.0)

41.2 ± 25.8 37.0 (35.0)

45.7 ± 26.8 44.0 (45.0)

CRP, mg/L

  

0.694

  

0.039

  

0.092

 

Mean ± SD Median (IQR)

32.0 ± 35.7 19.0 (34.0)

33.3 ± 35.4 19.5 (36.3)

28.9 ± 33.3 17.0 (28.8)

38.0 ± 38.0 23.0 (48.0)

29.9 ± 31.8 18.0 (31.0)

46.0 ± 48.3 23.5 (59.8)

IgG subclasses

IgG1– (n = 33)

IgG1 + (n = 149)

p

IgG2– (n = 100)

IgG2 + (n = 82)

p

IgG3– (n = 157)

IgG3 + (n = 25)

p

IgG4– (n = 98)

IgG4 + (n = 84)

p

ESR, mm/h

  

0.176

  

0.156

  

0.323

  

<0.001*

Mean ± SD Median (IQR)

36.8 ± 24.2 32.0 (26.0)

44.1 ± 27.3 37.0 (46.0)

40.4 ± 26.3 34.0 (39.0)

45.7 ± 27.4 44.5 (46.3)

42.1 ± 26.9 34.5 (45.0)

47.0 ± 26.6 51.0 (45.0)

35.3 ± 23.2 30.0 (29.3)

51.4 ± 28.3 49.0 (45.0)

CRP, mg/L

  

0.637

  

0.023

  

0.107

  

0.003*

Mean ± SD Median (IQR)

27.5 ± 26.1 20.0 (30.0)

34.7 ± 37.2 19.5 (39.3)

29.0 ± 33.1 17.5 (31.8)

38.7 ± 37.7 26.0 (41.0)

31.1 ± 33.4 18.0 (33.5)

47.5 ± 44.8 32.0 (58.5)

25.3 ± 27.2 16.0 (28.0)

42.1 ± 41.1 28.0 (52.0)

  1. Mann-Whitney U test to calculate P values for baseline parameters (ESR and CRP level)
  2. IgG subclass analysis was performed in anti-carbamylated protein IgG-positive patients
  3. Bold indicates a significant difference
  4. * Remained significant after Holm-Bonferroni correction
  5. Holm-Bonferroni correction was performed for independent analyses in whole cohort
  6. CRP C-reactive protein, ESR erythrocyte sedimentation rate, Ig immunoglobulin, IQR interquartile range, SD standard deviation