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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: Hydroxychloroquine inhibits CD154 expression in CD4+ T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling

Fig. 7

Proposed model for HCQ downregulation of CD154 expression. In this model based on our results, HCQ inhibits membrane CD154 expression through blocking intracellular Ca2+ signaling, thus keeping the NFAT transcription factor in an inactive state. TCR T-cell receptor, MHC major histocompatibility complex, IP3 inositol triphosphate, CRAC Ca2+ release-activated Ca2+, NFAT nuclear factor of activated T cells, HCQ hydroxychloroquine, IL interleukin, STAT5 signal transducer and activator of transcription 5

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Arthritis Research & Therapy

ISSN: 1478-6362

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