Fig. 5
From: The impact of age and gut microbiota on Th17 and Tfh cells in K/BxN autoimmune arthritis
Reduced T follicular helper (Tfh) proliferation and differentiation in middle-aged K/BxN mice. a Representative histogram overlays and quantitative data on Ki-67+ Tfh cells in the spleen from segmented filamentous bacteria-negative (SFB–) and SFB+ of young or middle-aged K/BxN mice (n = 4–14 mice of each group). b, c Representative histogram overlays of Bcl-6 expression in non-Tfh cells and quantitative data on normalized Bcl-6 mean fluorescence intensity (MFI) in non-Tfh and Tfh cells from the spleen (b) and Peyer’s patches (PPs) (c) from experiments shown in a. Bcl-6 MFI was normalized to splenic non-Tfh cells from one SFB– young mouse within each experiment