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Table 2 Gene enrichment of SS-related pathways using GeneCodis

From: Biosemantics guided gene expression profiling of Sjögren’s syndrome: a comparative analysis with systemic lupus erythematosus and rheumatoid arthritis

Annotations-biological processes

NG

Hyp_c*

1. GO:0019221: cytokine-mediated signaling pathway

15

5.95006e-17

2. GO:0006955: immune response

14

4.76772e-11

3. GO:0060337: type I interferon-mediated signaling pathway

8

1.42292e-09

4. GO:0006954: inflammatory response

11

2.46689e-09

5. GO:0007166: cell surface receptor signaling pathway

9

2.36659e-08

6. GO:0006935: chemotaxis

8

4.83921e-08

7. GO:0032496: response to lipopolysaccharide

8

7.63604e-08

8. GO:0071260: cellular response to mechanical stimulus

5

9.01203e-06

9. GO:0008284: positive regulation of cell proliferation

9

8.76728e-06

10. GO:0019882: antigen processing and presentation

5

9.656e-06

11. GO:0002544: chronic inflammatory response

3

2.33879e-05

12. GO:0045087: innate immune response

8

2.62163e-05

13. GO:0009615: response to virus

6

4.64203e-05

14. GO:0060333: interferon-gamma-mediated signaling pathway

5

5.66952e-05

15. GO:0032355: response to estradiol stimulus

5

7.95296e-05

16. GO:0007165: signal transduction

13

7.872e-05

  1. The 76 genes, found by concept profile analysis and differentially expressed in salivary glands of patients with Sjögren’s syndrome (SS), were grouped based on Gene Ontology (GO) [34, 65]. NG number of annotated genes in the input list of 76 differentially expressed genes
  2. *Hyp_c is the corrected hypergeometric p value