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Table 3 KEGG pathways of SS-related DE genes associated with diseases using GeneCodis

From: Biosemantics guided gene expression profiling of Sjögren’s syndrome: a comparative analysis with systemic lupus erythematosus and rheumatoid arthritis

 

Items

Disease

NG

Hyp_c*

Genes

1.

Kegg:05162

Measles

12

1.25E-14

STAT1, STAT2, OAS2, MX1, FAS, IFNG, DDX58, IL2RB, OAS1, IFIH1, TACR1, TLR7

2.

Kegg:05160

Hepatitis C

7

4.61E-07

STAT1, STAT2, OAS2, IFIT1, DDX58, OAS1, LDLR

3.

Kegg:05145

Toxoplasmosis

6

5.21E-06

STAT1, MAP2K3, IFNG, LY96, ITGB1, LDLR

4.

Kegg:05142

Chagas disease (American trypanosomiasis)

5

3.41E-05

FAS, IFNG, CALR, CD247, CFLAR

5.

Kegg:05152

Tuberculosis

3

2.06E-02

STAT1, CD74, IFNG

6.

Kegg:05140

Leishmaniasis

3

2.67E-03

STAT1, IFNG, ITGB1

7.

Kegg:05146

Amoebiasis

3

7.11E-03

IFNG, CD1D, COL5A1

8.

Kegg:05332

Graft-versus-host disease

3

3.43E-04

KLRC1, FAS, IFNG

9.

Kegg:05320

Autoimmune thyroid disease

2

1.49E-02

FAS, TSHR

10.

Kegg:05143

African trypanosomiasis

2

9.84E-03

FAS, IFNG

11.

Kegg:05412

Arrhythmogenic right ventricular cardiomyopathy

2

3.22E-02

LEF1, ITGB1

12.

Kegg:05130

Escherichia coli infection

2

2.05E-02

LY96, ITGB1

13.

Kegg:04940

Type I diabetes mellitus

2

1.00E-02

FAS, IFNG

14.

Kegg:05323

Rheumatoid arthritis

2

4.09E-02

CXCL5, IFNG

15.

Kegg:05212

Pancreatic cancer

2

3.07E-02

STAT1, RAD51

  1. List of diseases associated with the 76 differentially expressed (DE) genes in salivary glands of patients with Sjögren’s syndrome (SS) from the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. NG Number of genes out of the 76 DE genes
  2. *HYP_c is the corrected hypergeometric p value