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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: HM71224, a selective Bruton’s tyrosine kinase inhibitor, attenuates the development of murine lupus

Fig. 1

Inhibitory effects of HM71224 on B cell antigen receptor (BCR) and Fc receptor (FcR) signaling. a HM71224 dose-dependently inhibited BCR stimulation (1 μM of goat F(ab’)2 anti-human IgM)-induced phosphorylation of both Bruton’s tyrosine kinase (BTK) Y223 and phosphoinositide phospholipase C-γ2 (PLCγ2) Y1217 in Ramos cells. The western blots were reproduced three times and the representative one was chosen. b, c THP-1 cells (n = 2) were differentiated to macrophages by 10 ng/ml of interferon-γ. HM71224 treatment resulted in a trend toward reduction of IgG-induced TNF-α and IL-6 production by THP-1 cells. Data are shown as the mean ± SEM. GAPH glyceraldehyde 3-phosphate dehydrogenase

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