Fig. 5From: HM71224, a selective Bruton’s tyrosine kinase inhibitor, attenuates the development of murine lupusHM71224 limits renal impairment. Serum blood urea nitrogen (BUN) and creatinine (CRE) were measured at the end of the study. Treatment of MRL/lpr mice with HM71224 reduced BUN (a) but increased CRE was not observed at 28 weeks of age, even in vehicle-treated mice (b). Treatment of NZB/W F1 mice with HM71224 resulted in a significant decrease in BUN (c) and CRE (d) at 40 weeks of age. Data are shown as the mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001 versus vehicle control determined by analysis of variance (BUN and CRE in c and d) and the Kruskal–Wallis test (BUN in a)Back to article page