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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: HM71224, a selective Bruton’s tyrosine kinase inhibitor, attenuates the development of murine lupus

Fig. 5

HM71224 limits renal impairment. Serum blood urea nitrogen (BUN) and creatinine (CRE) were measured at the end of the study. Treatment of MRL/lpr mice with HM71224 reduced BUN (a) but increased CRE was not observed at 28 weeks of age, even in vehicle-treated mice (b). Treatment of NZB/W F1 mice with HM71224 resulted in a significant decrease in BUN (c) and CRE (d) at 40 weeks of age. Data are shown as the mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001 versus vehicle control determined by analysis of variance (BUN and CRE in c and d) and the Kruskal–Wallis test (BUN in a)

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