Fig. 6

HM71224 reduced glomerular dysfunction in animal models of lupus. The severity of urine protein concentration was graded using a urine protein scoring system. The percentage of mice with severe proteinuria (urine protein ≥ 300 mg/dl or urine protein score ≥ 3) sequentially increased in both mouse models (a, c). Especially, severe proteinuria in NZB/W F1 mice dramatically increased from 30 weeks of age in vehicle-treated mice, whereas few HM71224-treated mice had severe proteinuria c. The area under the curve (AUC) for the urine protein score in all treatment periods was significantly reduced in HM71224-treated groups in both mouse models (b, d). Data are shown as the mean ± SEM. **P < 0.01 and ****P < 0.0001 versus vehicle control determined by analysis of variance