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Fig. 8 | Arthritis Research & Therapy

Fig. 8

From: HM71224, a selective Bruton’s tyrosine kinase inhibitor, attenuates the development of murine lupus

Fig. 8

HM71224 increases the survival rate in animal models of lupus. a None of mice treated with HM71224 died through all by 20 weeks after administration compared to the survival rate of 92% (11/12) in vehicle treated MRL/lpr mice. b All mice treated with 10 and 30 mg/kg of HM71224 survived through all by 22 weeks following administration and had a statistically significantly better survival rate, whereas vehicle-treated mice and mice treated with 3 mg/kg of HM71224 had survival rates of 67% (8/12) and 75% (9/12), respectively, among NZB/W F1 mice (n = 12 per group). **P < 0.01 versus vehicle control determined by the log-rank test

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