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Table 4 Regression analyses with change in Larsen score between baseline and 12 months as dependent variable

From: Decrease in bone mineral density during three months after diagnosis of early rheumatoid arthritis measured by digital X-ray radiogrammetry predicts radiographic joint damage after one year

  Simple regression Multiple regression
Variable Adjusted R-square β-coeff p value Adjusted R-square β-coeff p value
DXR decrease (mg/cm2/month)a 0.049 −0.235 0.002 0.069 −0.181 0.033
DAS28b 0.015 0.148 0.070   0.028 0.767
Larsen scoreb 0.017 0.153 0.049   0.068 0.404
Ageb 0.001 0.082 0.291    
Gender 0.007 0.114 0.143   0.071 0.381
anti-CCP2 statusb 0.010 −0.125 0.107   −0.128 0.114
RFb −0.001 −0.069 0.385    
Corticosteroid treatment −0.002 0.042 0.417    
Disease duration (months)b −0.006 0.026 0.739    
CRP (mg/L)b −0.004 0.045 0.566    
ESR (mm/h)b 0.024 0.173 0.025   0.133 0.165
DAS28 > 2.6 at 3 months −0.002 0.065 0.422    
  1. Abbreviations: DXR digital X-ray radiogrammetry, DAS28 Disease Activity Score in 28 joints, CCP cyclic citrullinated peptides, RF rheumatoid factor, CRP C-reactive protein, ESR erythrocyte sedimentation rate, BMD bone mineral density
  2. aDecrease in DXR-BMD between baseline and 3 months
  3. bBaseline value