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Table 3 Comparison of laboratory variables in differentiating active SLE from inactive SLE, using logistic regression analysis

From: Decreased ex vivo production of interferon-gamma is associated with severity and poor prognosis in patients with lupus

 

Univariate analysis

Multivariate analysis

Odds ratio

95% CI

p value

Odds ratio

95% CI

p value

WBC count (/μL)

0.999

0.999–0.999

0.009

   

Haemoglobin (g/dL)

0.408

0.298–0.560

<0.001

   

Platelet count (×1000/μL)

0.992

0.988–0.997

0.001

   

Lymphocyte count (/μL)

0.997

0.996–0.998

<0.001

   

ESR (mm/h)

1.032

1.016–1.048

<0.001

   

CRP (mg/L)

1.081

1.029–1.137

0.002

   

BUN (mg/dL)

1.049

1.002–1.098

0.037

   

Cr (mg/dL)

2.964

0.935–9.396

0.064

   

Albumin (mg/dL)

0.022

0.005–0.084

<0.001

0.070

0.011–0.441

0.004

AST (IU/L)

1.099

1.048–1.153

<0.001

1.205

1.050–1.383

0.007

ALT (IU/L)

1.023

1.000–1.046

0.047

0.886

0.809–0.971

0.009

Total bilirubin (mg/dL)

1.064

0.747–1.518

0.728

   

Complement 3, mg/dL

0.951

0.934–0.969

<0.001

   

Complement 4, mg/dL

0.910

0.868–0.955

<0.001

   

Anti-dsDNA (IU/mL)

1.009

1.005–1.014

<0.001

   

Urine P/Cr ratio

5.874

1.772–19.470

0.003

   

Ex vivo IFN-γ production (IU/mL)

0.721

0.646–0.804

<0.001

   

Ex vivo IFN-γ production ≤ 7.19 IU/mL

36.257

12.789–102.788

<0.001

49.004

5.871–408.991

<0.001

Concurrent immunosuppressive treatment

0.054

0.017–0.170

<0.001

0.056

0.006–0.469

0.007

  1. AST aspartate aminotransferase, ALT alanine aminotransferase, BUN blood urea nitrogen, Cr creatinine, CRP C-reactive protein, ESR erythrocyte sedimentation rate, IFN-γ interferon gamma, P/Cr protein/creatinine, SLE systemic lupus erythematosus, WBC white blood cell