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Table 2 HLA-DRB1 allele carrier frequency in the patients with AOSD and in controls

From: Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still’s disease

 

Cases (n = 96)

Controls (n = 1026)

P

OR

Pc

95% CI

DRB1*01:01

9 (9.4)

110 (10.7)

0.8622

0.86

NS

(0.42–1.76)

DRB1*03:01

0 (0.0)

3 (0.3)

1.0000

1.52

NS

(0.08–29.55)

DRB1*04:01

0 (0.0)

22 (2.1)

0.2486

0.23

NS

(0.01–3.84)

DRB1*04:03

4 (4.2)

47 (4.6)

1.0000

0.91

NS

(0.32–2.57)

DRB1*04:04

0 (0.0)

4 (0.4)

1.0000

1.18

NS

(0.06–22.03)

DRB1*04:05

21 (21.9)

243 (23.7)

0.8014

0.90

NS

(0.54–1.49)

DRB1*04:06

2 (2.1)

76 (7.4)

0.0562

0.27

NS

(0.06–1.10)

DRB1*04:07

0 (0.0)

15 (1.5)

0.6313

0.34

NS

(0.02–5.70)

DRB1*04:10

4 (4.2)

32 (3.1)

0.5413

1.35

NS

(0.47–3.90)

DRB1*07:01

0 (0.0)

9 (0.9)

1.0000

0.55

NS

(0.03–9.61)

DRB1*08:02

13 (13.5)

72 (7.0)

0.0403

2.08

NS

(1.10–3.90)

DRB1*08:03

16 (16.7)

153 (14.9)

0.6544

1.14

NS

(0.65–2.01)

DRB1*08:09

0 (0.0)

2 (0.2)

1.0000

2.12

NS

(0.10–44.55)

DRB1*09:01

11 (11.5)

280 (27.3)

0.0004

0.34

0.0110

(0.18–0.66)

DRB1*10:01

0 (0.0)

5 (0.5)

1.0000

0.96

NS

(0.05–17.54)

DRB1*11:01

6 (6.3)

41 (4.0)

0.2837

1.60

NS

(0.66–3.87)

DRB1*12:01

16 (16.7)

75 (7.3)

0.0031

2.54

0.0896

(1.41–4.56)

DRB1*12:02

8 (8.3)

37 (3.6)

0.0488

2.43

NS

(1.10–5.38)

DRB1*13:01

2 (2.1)

8 (0.8)

0.2082

2.71

NS

(0.57–12.93)

DRB1*13:02

5 (5.2)

163 (15.9)

0.0040

0.29

0.1150

(0.12–0.73)

DRB1*14:03

7 (7.3)

44 (4.3)

0.1941

1.76

NS

(0.77–4.01)

DRB1*14:04

0 (0.0)

4 (0.4)

1.0000

1.18

NS

(0.06–22.03)

DRB1*14:05

6 (6.3)

40 (3.9)

0.2758

1.64

NS

(0.68–3.98)

DRB1*14:06

2 (2.1)

29 (2.8)

1.0000

0.73

NS

(0.17–3.11)

DRB1*14:07

0 (0.0)

2 (0.2)

1.0000

2.12

NS

(0.10–44.55)

DRB1*14:54

6 (6.3)

58 (5.7)

0.8168

1.11

NS

(0.47–2.65)

DRB1*15:01

31 (32.3)

139 (13.5)

8.60 × 10-6

3.04

0.0002

(1.91–4.84)

DRB1*15:02

18 (18.8)

224 (21.8)

0.5197

0.83

NS

(0.48–1.41)

DRB1*16:02

0 (0.0)

18 (1.8)

0.3919

0.28

NS

(0.02–4.72)

DR5(*11, *12)

28 (29.2)

151 (14.7)

0.0006

2.39

 

(1.49–3.83)

  1. Allele carrier frequencies are shown in parentheses (%). Association was tested by Fisher’s exact test using 2 × 2 contingency tables under the dominant model. AOSD adult onset Still’s disease, OR odds ratio, CI confidence interval, Pc corrected p value, NS not significant