Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 HLA-DRB1 allele carrier frequency in the patients with AOSD and in controls

From: Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still’s disease

  Cases (n = 96) Controls (n = 1026) P OR Pc 95% CI
DRB1*01:01 9 (9.4) 110 (10.7) 0.8622 0.86 NS (0.42–1.76)
DRB1*03:01 0 (0.0) 3 (0.3) 1.0000 1.52 NS (0.08–29.55)
DRB1*04:01 0 (0.0) 22 (2.1) 0.2486 0.23 NS (0.01–3.84)
DRB1*04:03 4 (4.2) 47 (4.6) 1.0000 0.91 NS (0.32–2.57)
DRB1*04:04 0 (0.0) 4 (0.4) 1.0000 1.18 NS (0.06–22.03)
DRB1*04:05 21 (21.9) 243 (23.7) 0.8014 0.90 NS (0.54–1.49)
DRB1*04:06 2 (2.1) 76 (7.4) 0.0562 0.27 NS (0.06–1.10)
DRB1*04:07 0 (0.0) 15 (1.5) 0.6313 0.34 NS (0.02–5.70)
DRB1*04:10 4 (4.2) 32 (3.1) 0.5413 1.35 NS (0.47–3.90)
DRB1*07:01 0 (0.0) 9 (0.9) 1.0000 0.55 NS (0.03–9.61)
DRB1*08:02 13 (13.5) 72 (7.0) 0.0403 2.08 NS (1.10–3.90)
DRB1*08:03 16 (16.7) 153 (14.9) 0.6544 1.14 NS (0.65–2.01)
DRB1*08:09 0 (0.0) 2 (0.2) 1.0000 2.12 NS (0.10–44.55)
DRB1*09:01 11 (11.5) 280 (27.3) 0.0004 0.34 0.0110 (0.18–0.66)
DRB1*10:01 0 (0.0) 5 (0.5) 1.0000 0.96 NS (0.05–17.54)
DRB1*11:01 6 (6.3) 41 (4.0) 0.2837 1.60 NS (0.66–3.87)
DRB1*12:01 16 (16.7) 75 (7.3) 0.0031 2.54 0.0896 (1.41–4.56)
DRB1*12:02 8 (8.3) 37 (3.6) 0.0488 2.43 NS (1.10–5.38)
DRB1*13:01 2 (2.1) 8 (0.8) 0.2082 2.71 NS (0.57–12.93)
DRB1*13:02 5 (5.2) 163 (15.9) 0.0040 0.29 0.1150 (0.12–0.73)
DRB1*14:03 7 (7.3) 44 (4.3) 0.1941 1.76 NS (0.77–4.01)
DRB1*14:04 0 (0.0) 4 (0.4) 1.0000 1.18 NS (0.06–22.03)
DRB1*14:05 6 (6.3) 40 (3.9) 0.2758 1.64 NS (0.68–3.98)
DRB1*14:06 2 (2.1) 29 (2.8) 1.0000 0.73 NS (0.17–3.11)
DRB1*14:07 0 (0.0) 2 (0.2) 1.0000 2.12 NS (0.10–44.55)
DRB1*14:54 6 (6.3) 58 (5.7) 0.8168 1.11 NS (0.47–2.65)
DRB1*15:01 31 (32.3) 139 (13.5) 8.60 × 10-6 3.04 0.0002 (1.91–4.84)
DRB1*15:02 18 (18.8) 224 (21.8) 0.5197 0.83 NS (0.48–1.41)
DRB1*16:02 0 (0.0) 18 (1.8) 0.3919 0.28 NS (0.02–4.72)
DR5(*11, *12) 28 (29.2) 151 (14.7) 0.0006 2.39   (1.49–3.83)
  1. Allele carrier frequencies are shown in parentheses (%). Association was tested by Fisher’s exact test using 2 × 2 contingency tables under the dominant model. AOSD adult onset Still’s disease, OR odds ratio, CI confidence interval, Pc corrected p value, NS not significant