Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still’s disease

Table 5 HLA-DRB1 allele carrier frequency in the patients with AOSD with or without MEFV variants

	AOSD with MEFV variants	AOSD without MEFV variants	Controls	AOSD with MEFV variants vs. controls				AOSD without MEFV variants vs. controls
	(n = 49)	(n = 38)	(n = 1026)	P	OR	Pc	95% CI	P	OR	Pc	95% CI
DRB115:01*	17 (34.7)	13 (34.2)	139 (13.5)	0.0002	3.39	0.0068	(1.83–6.27)	0.0013	3.32	0.0388	(1.66–6.64)
DR5(DRB111, 12)	16 (32.7)	8 (21.1)	151 (14.7)	0.0019	2.81		(1.51–5.23)	0.2543	1.55		(0.70–3.43)

Allele carrier frequencies are shown in parentheses (%). Association was tested by Fisher’s exact test using 2 × 2 contingency tables under the dominant model. AOSD adult onset Still’s disease, OR odds ratio, CI confidence interval, Pc corrected p value, NS not significant

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