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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model

Fig. 1

17β-estradiol (E2) treatment suppressed arthritis development in SKG mice. Clinical scores were markedly suppressed in E2-treated mice compared with mice in the sham-operated (Sham) and ovariectomized (OVx) groups after 31 days of zymosan injection. Clinical scores (a), the incidence of arthritis (b), the incidence of tail changes (c), body weight (d), and the incidence of blepharitis (e) in the three groups. Serum levels of E2 were measured by ELISA (f). Values are mean ± SEM (n = 16 mice per group); *P < 0.05, **P < 0.01, ***P < 0.001 (sham vs. OVx + E2); # P < 0.05; ## P < 0.01; ### P < 0.001 (OVx vs. OVx + E2)

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