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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model

Fig. 3

The effect of estrogen on microscopic inflammation. a-d The intervertebral area of the wild-type control (a), sham-operated (Sham) (b), ovariectomized (OVx) (c), and 17β-estradiol (E2)-treated (OVx + E2) mice (d). Arrows in b and c indicate inflammatory cell infiltration of the intervertebral disc area. e-f Achilles tendon of the normal control (e), sham (f), ovariectomized (g), and E2-treated mice (h). Arrows in f and g indicate inflammatory cell infiltration in the Achilles tendon. Inflammatory cell infiltration was not evident in E2-treated mice. Staining with H&E. Original magnification × 40. Histologic severity scores for peripheral joints affected by peripheral arthritis, including the forepaws, hind paws, ankle joints (i), tail (j), and intestine (k). Symbols represent individual mice, horizontal lines represent the mean, and whiskers represent the SEM; n = 16 mice per group except for the wild-type control (n = 2); *P < 0.05, **P < 0.01, ***P < 0.001 versus controls

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