Skip to main content

Advertisement

Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Table 1 Patient characteristics, disease activity, and patient-reported outcomes at baseline*

From: Patient-reported outcomes of baricitinib in patients with rheumatoid arthritis and no or limited prior disease-modifying antirheumatic drug treatment

Parametera MTX (N = 210) Baricitinib 4 mg (N = 159) Baricitinib 4 mg + MTX (N = 215)
Age, years 50.5 (13) 50.9 (13) 48.5 (14)
Female, n (%) 148 (70) 121 (76) 156 (73)
Duration of RA, years 1.3 (4.0) 1.9 (4.7) 1.3 (2.7)
Duration of RA, years, median 0.2 0.2 0.2
Concomitant corticosteroid use, n (%) 76 (36) 47 (30) 83 (39)
Number of previous cDMARDs used, n (%)
 0 190 (90) 146 (92) 197 (92)
 1 20 (10) 13 (8) 18 (8)
 2 0 0 0
Ever used DMARD (≤ 3 doses of MTX permitted), n (%) 20 (10) 13 (8) 18 (8)
Disease activity
 Swollen joint count, of 66 16 (11) 16 (9) 16 (10)
 Tender joint count, of 68 27 (15) 26 (14) 28 (15)
 DAS28-hsCRP 5.9 (1.0) 5.9 (1.0) 5.9 (0.9)
 DAS28-ESR 6.6 (1.0) 6.6 (1.1) 6.6 (1.0)
 Simplified Disease Activity Index 42 (14) 43 (14) 43 (13)
 Clinical Disease Activity Index 39 (13) 40 (13) 40 (13)
Patient-reported outcomes
 HAQ-DI (0–3) 1.7 (0.7) 1.6 (0.7) 1.6 (0.7)
 PtGA VAS (0–100) 66 (24) 65 (22) 63 (24)
 Patient’s assessment of pain, VAS (0–100) 65 (24) 64 (22) 63 (23)
 Fatigue (FACIT-F; 0–52) 27 (11) 28 (11) 28 (11)
 Median (IQR) duration of morning joint stiffness, minutes 90 (30, 180) 60 (30, 180) 90 (30, 180)
 Worst Joint Pain NRS (0–10) 7 (2) 7 (2) 7 (2)
 Worst Tiredness NRS (0–10) 6 (2) 6 (3) 6 (2)
QoL (SF-36; 0–100)
 PCS 32 (8) 33 (8) 32 (9)
 MCS 47 (12) 45 (13) 47 (13)
EQ-5D
 Health State Index Score, UK algorithm (-0.594,1) 0.473 (0.256) 0.485 (0.255) 0.489 (0.251)
 Self-perceived health score VAS (0–100) 51 (23) 50 (23) 51 (23)
  1. Score ranges for individual patient-reported outcomes measures are indicated in brackets. Lower scores indicate better outcomes for HAQ-DI, PtGA, patient’s assessment of pain, Worst Joint Pain, Worst Tiredness. Higher scores indicate better outcomes for FACIT-F, SF-36 and EQ-5D
  2. EQ-5D European Quality of Life-5 Dimensions, FACIT-F Functional Assessment of Chronic Illness Therapy–Fatigue, HAQ-DI Health Assessment Questionnaire-Disability Index, IQR interquartile range, MCS Mental Component Score, MTX methotrexate, NRS numeric rating scale, PCS Physical Component Score, PtGA Patient’s Global Assessment of Disease Activity, QoL quality of life, RA rheumatoid arthritis, SF-36 Short Form-36, UK United Kingdom, VAS visual analog scale
  3. aData are presented as mean (standard deviation) unless stated otherwise
  4. *Further details can be found in Fleischmann et al. 2017 [1]