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Table 3 Work Productivity and Activity Impairment Questionnaire - Rheumatoid Arthritis (WPAI-RA): impairment of regular activities among all patients at baseline and least-squares mean change from baseline at week 24 and at week 52

From: Patient-reported outcomes of baricitinib in patients with rheumatoid arthritis and no or limited prior disease-modifying antirheumatic drug treatment

WPAI-RA question administered to all patientsa

 

Baseline, Mean (SD)

Week 24, LSM (95% CI)

Week 52, LSM (95% CI)

 

MTX (N = 210)

Baricitinib 4 mg (N = 159)

Baricitinib 4 mg + MTX (N = 215)

MTX (N = 210)

Baricitinib 4 mg (N = 159)

Baricitinib 4 mg + MTX (N = 215)

MTX (N = 210)

Baricitinib 4 mg (N = 159)

Baricitinib 4 mg + MTX (N = 215)

Percent activity impairment due to RA

61 (26)

62 (25)

59 (25)

− 25 (− 29, − 22)

− 37 (− 40, − 33)***

− 33 (− 37, − 30)***

− 29 (− 32, −25)

− 35 (− 38, − 31)*

− 38 (− 42, − 35)***

  1. CI confidence interval, LSM least-squares mean, MTX methotrexate, RA rheumatoid arthritis
  2. aData are presented as mean (standard deviation) unless stated otherwise
  3. *p ≤ 0.05; ***p ≤ 0.001 vs. MTX