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Table 2 Serum bone biomarker concentrations in disease groups compared with the reference healthy control group

From: Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: a prospective cross-sectional comparative study

Group Serum concentration ng/mL
Median (IQR)
Adjusted odds ratio* (per ng/mL increase in concentration) 95% CI p value
Dkk-1 (^Homogeneity p value = 0.08)
HC 3.52 (2.72, 4.46)    
PsC 2.50 (1.87, 3.42) 0.72 0.61, 0.86 2 × 10−4
pPsA 3.03 (1.93, 3.69) 0.88 0.74, 1.04 0.14
PsSpA 3.34 (2.43, 4.44) 1.00 0.87, 1.15 0.99
AS 3.51 (2.92, 4.58) 1.10 0.97, 1.25 0.13
M-CSF (^Homogeneity p value = 0.26)
HC 0.81 (0.41, 0.99)    
PsC 0.62 (0.25, 0.88) 0.59 0.32, 1.08 0.09
pPsA 0.29 (0.16, 0.68) 0.14 0.06, 0.32 <1 × 10−5
PsSpA 0.27 (0.17, 0.64) 0.07 0.03, 0.17 <1 × 10−8
AS 0.32 (0.17, 0.58) 0.37 0.16, 0.85 <1 × 10−7
MMP-3 (^Homogeneity p value = 4 × 10−4)
HC 16.67 (9.74, 20.64)    
PsC 13.13 (9.52, 18.37) 1.05 1.00, 1.09 0.06
pPsA 16.54 (11.77, 26.84) 1.06 1.01, 1.10 0.02
PsSpA 19.83 (11.32, 29.60) 1.06 1.01, 1.11 0.02
AS 19.73 (14.90, 28.02) 1.06 1.01, 1.11 0.01
OPG (^Homogeneity p value = 5 × 10−8)
HC 0.153 (0.116, 0.173)    
PsC 0.165 (0.130, 0.211) 8.80 0.25, 309.42 0.23
pPsA 0.190 (0.118, 0.285) 25.77 0.72, 913.42 0.07
PsSpA 0.165 (0.121, 0.244) 8.72 0.23, 334.50 0.24
AS 0.165 (0.102, 0.221) 4.78 0.12, 198.22 0.41
  1. 95% CI 95% confidence interval, AS ankylosing spondylitis, HC healthy control, PsC psoriasis without arthritis, pPsA peripheral-only PsA, PsSpA psoriatic spondyloarthropathy, Dkk-1 Dickkopf 1, MMP-3 matrix metalloproteinase 3, M-CSF macrophage colony stimulating factor, OPG osteoprotegerin
  2. n = 143 AS, 41 HC, 108 pPsA, 194 PsC, 117 PsSpA
  3. ^Multinomial logistic regression: homogeneity p value tests for no difference in the concentration of each biomarker across all five groups (adjusted for sex, age at blood sampling, and the other biomarkers)
  4. *Multinomial logistic regression comparing HC with each of the 4 disease groups (adjusted for sex, age at blood sampling, and other biomarkers)