Skip to main content

Table 4 Biomarker concentration thresholds differentiating disease groups, using receiver operating characteristic analyses

From: Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: a prospective cross-sectional comparative study

  Maximum accuracy(proportion of cases correctly classified) Minimum value forsensitivity ≥ 0.95
  PsC vs. PsA HC vs. PsA PsC vs. PsA HC vs. PsA
  MMP-3
Threshold (ng/mL) 14.51 7.21 8.22 8.32
Sensitivity 0.76 0.99 0.96 0.95
Specificity 0.60 0.12 0.16 0.20
AUC (95% CI) 0.70 (0.65, 0.75) 0.66 (0.59, 0.74) 0.70 (0.65, 0.75) 0.66 (0.59, 0.74)
  M-CSF
Threshold (ng/mL) 0.05 0.02 0.10 0.02
Sensitivity 0.99 1.00 0.95 1.00
Specificity 0.01 0.00 0.02 0.00
AUC (95% CI) 0.34 (0.29, 0.40) 0.24 (0.17, 0.31) 0.34 (0.29, 0.40) 0.24 (0.17, 0.31)
  PsA cases: Non-RAD vs. RAD PsA cases: Non-RAD vs. RAD
  Dkk-1
Threshold (ng/mL) 4.96 0.91
Sensitivity 0.15 0.96
Specificity 0.94 0.05
AUC (95% CI) 0.56 (0.44, 0.67) 0.56 (0.44, 0.67)
  OPG
Threshold (ng/mL) 3.88 0.08
Sensitivity 0.00 0.95
Specificity 0.99 0.08
AUC (95% CI) 0.47 (0.39, 0.56) 0.47 (0.39, 0.56)
  1. AUC area under the curve, 95CI 95% confidence interval, Dkk-1 Dickkopf 1, M-CSF Macrophage colony stimulating factor, MMP-3 Matrix metalloproteinase 3, OPG osteoprotegerin, PsA psoriatic arthritis, PsC psoriasis without arthritis, HC healthy control, RAD radiographic axial disease