Skip to main content

Table 4 Biomarker concentration thresholds differentiating disease groups, using receiver operating characteristic analyses

From: Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: a prospective cross-sectional comparative study

 

Maximum accuracy(proportion of cases correctly classified)

Minimum value forsensitivity ≥ 0.95

 

PsC vs. PsA

HC vs. PsA

PsC vs. PsA

HC vs. PsA

 

MMP-3

Threshold (ng/mL)

14.51

7.21

8.22

8.32

Sensitivity

0.76

0.99

0.96

0.95

Specificity

0.60

0.12

0.16

0.20

AUC (95% CI)

0.70 (0.65, 0.75)

0.66 (0.59, 0.74)

0.70 (0.65, 0.75)

0.66 (0.59, 0.74)

 

M-CSF

Threshold (ng/mL)

0.05

0.02

0.10

0.02

Sensitivity

0.99

1.00

0.95

1.00

Specificity

0.01

0.00

0.02

0.00

AUC (95% CI)

0.34 (0.29, 0.40)

0.24 (0.17, 0.31)

0.34 (0.29, 0.40)

0.24 (0.17, 0.31)

 

PsA cases: Non-RAD vs. RAD

PsA cases: Non-RAD vs. RAD

 

Dkk-1

Threshold (ng/mL)

4.96

0.91

Sensitivity

0.15

0.96

Specificity

0.94

0.05

AUC (95% CI)

0.56 (0.44, 0.67)

0.56 (0.44, 0.67)

 

OPG

Threshold (ng/mL)

3.88

0.08

Sensitivity

0.00

0.95

Specificity

0.99

0.08

AUC (95% CI)

0.47 (0.39, 0.56)

0.47 (0.39, 0.56)

  1. AUC area under the curve, 95CI 95% confidence interval, Dkk-1 Dickkopf 1, M-CSF Macrophage colony stimulating factor, MMP-3 Matrix metalloproteinase 3, OPG osteoprotegerin, PsA psoriatic arthritis, PsC psoriasis without arthritis, HC healthy control, RAD radiographic axial disease