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Table 2 Carotid intima-media thickness and brain magnetic resonance imaging assessments

From: Assessment of intracranial vessels in association with carotid atherosclerosis and brain vascular lesions in rheumatoid arthritis

  RA total (n = 41) RA MTX (n = 12) RA biologic (n = 29) Control subjects (n = 60) p Value
RA total vs control subjects RA MTX vs control subjects RA biologic vs control subjects RA MTX vs RA biologic
Carotid ultrasound studies
 Right cIMT (mm) 0.72 ± 0.24 0.72 ± 0.25 0.72 ± 0.23 0.40 ± 0.28 <0.001 <0.001 <0.001  
 Left cIMT (mm) 0.73 ± 0.23 0.69 ± 0.22 0.75 ± 0.24 0.40 ± 0.28 <0.001 <0.001 <0.001  
 Right carotid plaques (%) 21 (51%) 8 (67%) 13 (45%) 16 (27%) 0.021 0.016   
 Left carotid plaques (%) 18 (44%) 6 (50%) 12 (41%) 21 (35%)     
 Right carotid plaque score 1.22 ± 1.35 1.58 ± 1.31 1.07 ± 1.36 0.60 ± 0.99 0.016 0.008   
 Left carotid plaque score 1.00 ± 1.16 1.25 ± 1.55 0.90 ± 0.98 0.78 ± 1.12     
Brain MRI studies
 Right vascular lesions (%) 16 (39%) 5 (42%) 11 (38%)      
 Left vascular lesions (%) 16 (39%) 5 (42%) 11 (38%)      
 Emollition 2 (5%) 0 2 (7%)      
 Atrophy 8 (20%) 1 (8%) 7 (24%)      
  1. Abbreviations: cIMT Carotid intima-media thickness, MRI Magnetic resonance imaging, MTX Methotrexate, RA Rheumatoid arthritis