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Table 2 Linear mixed model analyses to assess effect of treatment intensification on change in Health Assessment Questionnaire

From: Further Treatment Intensification in Undifferentiated and Rheumatoid Arthritis Patients Already in Low Disease Activity has Limited Benefit towards Physical Functioning

  β 95% CI p Value
Model 1 (n patients = 479, n visits = 1528)
 Treatment intensification −0.085 −0.13 to −0.044 < 0.001
 Follow-up timea 0.0057 0.00094 to 0.010 0.019
Model 2 (n patients = 476, n visits = 1509)
 Treatment intensification −0.022 −0.060 to 0.016 0.246
 Follow-up timea 0.0022 −0.0021 to 0.0066 0.313
 DAS change 0.23 0.21 to 0.26 < 0.001
Model 3 (n patients = 476, n visits = 1509)
 Treatment intensification −0.10 −0.18 to −0.021 0.013
 Follow-up timea −0.0034 −0.010 to 0.0033 0.323
 Treatment intensification × follow-up time 0.0098 0.0010 to 0.019 0.029
 DAS change 0.23 0.21 to 0.26 < 0.001
  1. DAS Disease Activity Score in 44/53 joints
  2. aFollow-up time is added to the model as visit number, with time between visits being 4 months. All models were adjusted for baseline Health Assessment Questionnaire, sex, age and treatment arm