Further Treatment Intensification in Undifferentiated and Rheumatoid Arthritis Patients Already in Low Disease Activity has Limited Benefit towards Physical Functioning

Table 2 Linear mixed model analyses to assess effect of treatment intensification on change in Health Assessment Questionnaire

	β	95% CI	p Value
Model 1 (n patients = 479, n visits = 1528)
Treatment intensification	−0.085	−0.13 to −0.044	< 0.001
Follow-up time^a	0.0057	0.00094 to 0.010	0.019
Model 2 (n patients = 476, n visits = 1509)
Treatment intensification	−0.022	−0.060 to 0.016	0.246
Follow-up time^a	0.0022	−0.0021 to 0.0066	0.313
DAS change	0.23	0.21 to 0.26	< 0.001
Model 3 (n patients = 476, n visits = 1509)
Treatment intensification	−0.10	−0.18 to −0.021	0.013
Follow-up time^a	−0.0034	−0.010 to 0.0033	0.323
Treatment intensification × follow-up time	0.0098	0.0010 to 0.019	0.029
DAS change	0.23	0.21 to 0.26	< 0.001

DAS Disease Activity Score in 44/53 joints
^aFollow-up time is added to the model as visit number, with time between visits being 4 months. All models were adjusted for baseline Health Assessment Questionnaire, sex, age and treatment arm

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