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Table 1 Overview of animals used in experiments

From: S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis

Experiment Readout Time point Number of animals per group and strains
CiOA/control Monocyte populations and RNA expression synovium and BM Day 7 6 CiOA/6 control C57BL/6
6 CiOA/6 control S100a9-/-
CiOA/control BM count Day 7, 21, and 42 6 CiOA/7 control C57BL/6 (day 7)
6 CiOA/7 control C57BL/6 (day 21)
7 CiOA/7 control C57BL/6 (day 42)
CiOA/control Monocyte populations and BM count Day 7 5 CiOA/5 control C57BL/6
5 CiOA/5 control S100a9-/-
CiOA Immunohistologic evaluation (and serum for protein analysis) Day 7, 21, and 42 10 per time-point C57BL/6 (day 7)
10 per time-point S100a9-/- (day 7)
10 per time-point C57BL/6 (day 21)
10 per time-point S100a9-/- (day 21)
10 per time-point C57BL/6 (day 42)
10 per time-point S100a9-/- (day 42)
i.a. injection with S100A8/BSA Immunohistologic evaluation Day 1 8 C57BL/6
i.a. injection with S100A8/BSA RNA expression Day 1 6 C57BL/6
  1. CiOA collagenase-induced osteoarthritis, i.a., intra-articular, BM bone marrow