|
CiOA/control
|
Monocyte populations and RNA expression synovium and BM
|
Day 7
|
6 CiOA/6 control C57BL/6
|
|
6 CiOA/6 control S100a9-/-
|
|
CiOA/control
|
BM count
|
Day 7, 21, and 42
|
6 CiOA/7 control C57BL/6 (day 7)
|
|
6 CiOA/7 control C57BL/6 (day 21)
|
|
7 CiOA/7 control C57BL/6 (day 42)
|
|
CiOA/control
|
Monocyte populations and BM count
|
Day 7
|
5 CiOA/5 control C57BL/6
|
|
5 CiOA/5 control S100a9-/-
|
|
CiOA
|
Immunohistologic evaluation (and serum for protein analysis)
|
Day 7, 21, and 42
|
10 per time-point C57BL/6 (day 7)
|
|
10 per time-point S100a9-/- (day 7)
|
|
10 per time-point C57BL/6 (day 21)
|
|
10 per time-point S100a9-/- (day 21)
|
|
10 per time-point C57BL/6 (day 42)
|
|
10 per time-point S100a9-/- (day 42)
|
|
i.a. injection with S100A8/BSA
|
Immunohistologic evaluation
|
Day 1
|
8 C57BL/6
|
|
i.a. injection with S100A8/BSA
|
RNA expression
|
Day 1
|
6 C57BL/6
|
