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Table 1 Overview of animals used in experiments

From: S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis

Experiment

Readout

Time point

Number of animals per group and strains

CiOA/control

Monocyte populations and RNA expression synovium and BM

Day 7

6 CiOA/6 control C57BL/6

6 CiOA/6 control S100a9-/-

CiOA/control

BM count

Day 7, 21, and 42

6 CiOA/7 control C57BL/6 (day 7)

6 CiOA/7 control C57BL/6 (day 21)

7 CiOA/7 control C57BL/6 (day 42)

CiOA/control

Monocyte populations and BM count

Day 7

5 CiOA/5 control C57BL/6

5 CiOA/5 control S100a9-/-

CiOA

Immunohistologic evaluation (and serum for protein analysis)

Day 7, 21, and 42

10 per time-point C57BL/6 (day 7)

10 per time-point S100a9-/- (day 7)

10 per time-point C57BL/6 (day 21)

10 per time-point S100a9-/- (day 21)

10 per time-point C57BL/6 (day 42)

10 per time-point S100a9-/- (day 42)

i.a. injection with S100A8/BSA

Immunohistologic evaluation

Day 1

8 C57BL/6

i.a. injection with S100A8/BSA

RNA expression

Day 1

6 C57BL/6

  1. CiOA collagenase-induced osteoarthritis, i.a., intra-articular, BM bone marrow