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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis

Fig. 5

Association of marker levels with disease severity in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). a Association of transketolase (TKT) and CD93 levels with European Vasculitis Study Group-defined disease severity. Left panels: Comparison of the levels of each marker among the four groups: localized (n = 5), early systemic (n = 37), generalized (n = 96), and severe (n = 31) disease. Right panels: Comparison of the levels of each marker between patients with severe disease (n = 31) and the other three groups (n = 138). b Association of the level of each marker with rapidly progressive glomerulonephritis (RPGN) clinical grading. Serum levels of each marker were compared between grades I + II (n = 126) and grades III + IV (n = 43). c AUC score for each marker distinguishing between RPGN clinical grades I + II (n = 126) and grades III + IV (n = 43). d Association of TKT and CD93 levels with the Five-Factor Score 2009 (FFS). Left panels: Comparison of each marker among the three groups: ≤ l, 2, and ≥ 3 points (≤ 1, n = 67; 2, n = 57; and ≥ 3, n = 45). Right panels: Comparison of the level of each marker between the patients with ≤ 1 + 2 points (n = 124) and those with ≥ 3 points (n = 45). Statistical analysis is described in the Fig. 3 legend. *p < 0.05; **p < 0.01; ***p < 0.001. n.s. Not significant, CRP C-reactive protein, TIMP1 Tissue inhibitor of metalloproteinase 1, TNC Tenascin C

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