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Table 1 Baseline characteristics of the 169 patients with antineutrophil cytoplasmic antibody-associated vasculitis

From: Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis

  All (n = 169) MPA (n = 105) GPA (n = 36) EGPA (n = 25)
Male/female, n/n 65/104 45/60 14/22 6/19
Age, years 71 (61–78) 73 (66–78) 69 (60–79) 60 (46–70)
MPO-ANCA-positive 137 (81.1%) 103 (98.1%) 22 (61.1%) 9 (36%)
PR3-ANCA-positive 20 (12.2%) 4 (4.0%) 15 (41.7%) 1 (4.2%)
ANCA-negative 18 (10.7%) 1 (1.0%) 1 (2.8%) 16 (64%)
WBC, count/μl 9400 (7000–14,300) 8500 (6200–12,300) 9950 (7825–14,050) 19,200 (15,090–27,700)
Serum creatinine, mg/dl 0.92 (0.66–2.43) 1.41 (0.81–3.56) 0.71 (0.61–1.24) 0.59 (0.44–0.76)
eGFR, ml/minute/1.73 m2 50 (17–74) 34 (12–61) 65 (41–75) 81 (68–107)
Disease activity and organ involvement
 BVAS score 16 (12–21) 15 (12–19) 19 (12–24) 17 (14–20)
 BVAS chest positive 75 (44.4%) 43 (41%) 17 (47.2%) 15 (60%)
 BVAS renal positive 120 (71%) 92 (87.6%) 23 (63.9%) 4 (16%)
Disease severity
 EUVAS disease severity, L/ES/Ge/Se, n 5/37/96/31 2/27/52/24 3/7/23/3 0/1/20/14
 RPGN clinical grading, I/II/III/IV, n 40/86/38/5 18/54/28/5 8/21/7/0 14/9/2/0
 Five-Factor Score, ≤ 1/2/≥ 3, n 67/57/45 18/43/44 29/7/0 20/4/1
Outcomes at 6 months
 Clinical remission (BVAS score = 0) 121/157 (77.1%) 71/95 (74.7%) 28/35 (80%) 19/24 (79.2%)
 ESRD 15/157 (9.6%) 14/95 (14.7%) 1/35 (2.9%) 0/24 (0.0%)
  1. Abbreviations: eGFR Estimated glomerular filtration rate, BVAS Birmingham Vasculitis Activity Score version 3, EUVAS European Vasculitis Study Group, L/ES/Ge/Se Localized/early systemic/generalized/severe, RPGN Rapidly progressive glomerulonephritis, ESRD End-stage renal disease, MPO Myeloperoxidase, ANCA Antineutrophil cytoplasmic antibody, PR3 Proteinase-3, WBC White blood cell count, EGPA Eosinophilic granulomatosis with polyangiitis, GPA Granulomatosis with polyangiitis, MPA Microscopic polyangiitis
  2. Values are median (IQR) or n (%)