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Table 2 Clinical features and radiological imaging scores in each treatment group from baseline and 3 months follow up in all patients with rheumatoid arthritis who had a 3-month follow-up visit

From: Assessment of 3-month changes in bone microstructure under anti-TNFα therapy in patients with rheumatoid arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT)

Total (n = 22) MTX only group (n = 9) MTX + anti-TNFα group (n = 13)
Mean ± SD Baseline 3 Months Changes p value* Baseline 3 Months Changes p value*
Disease activity
 Swollen joints 0.7 ± 1.0 1.6 ± 1.8 0.9 ± 1.8 0.184 14.5 ± 3.9 6.3 ± 4.8 -8.2 ± 6.6 <0.001
 Tender joints 0.7 ± 1.1 1.0 ± 1.3 0.3 ± 1.2 0.438 9.3 ± 6.2 4.4 ± 9.5 -4.9 ± 9.9 0.086
 Global assessment of patient 7.4 ± 15.3 16.3 ± 25.7 8.9 ± 19.6 0.210 62.2 ± 16.8 41.4 ± 31.2 -20.8 ± 26.6 0.015
 Physician 11.7 ± 10.9 14.1 ± 12.6 2.4 ± 9.4 0.459 42.8 ± 10.7 26.4 ± 12.1 -16.4 ± 18.2 0.005
 ESR unm h) (mm/h) 18.0 ± 22.3 21.0 ± I8.3 3.0 ± 10.9 0.435 32.2 ± 21.9 29.7 ± 21.6 -2.4 ± 12.9 0.490
 CRP tmg/L) (mg/L) 2.1 ± 1.1 4.6 ± 3.5 2.4 ± 2.9 0.034 21.9 ± 28.1 10.4 ± 9.8 -11.5 ± 22.2 0.088
 DAS-28-ESR 1.9 ± 0.9 2.6 ± 0.9 0.7 ± 1.2 0.106 5.7 ± 1.1 3.8 ± 1.2 -2.0 ± 0.9 <0.001
 DAS-28-CRP l.8 ± 0.7 2.4 ± 0.8 0.6 ± 0.6 0.032 5.4 ± 0.9 3.5 ± 1.0 -I.7 ± 1.1 <0.001
 HAQ 0.5 ± 0.7 0.7 ± 0.8 0.2 ± 0.3 0.084 1.6 ± 0.7 1.0 ± 0.7 -0.6 ± 0.6 0.001
Modified SHARP score
 Total 4.7 ± 6.0 NA NA   26.1 ± 42.0 NA NA  
 Erosion 1.6 ± 2.6     13.5 ± 26.8    
 JSN 3.1 ± 4.9     12.5 ± 17.0    
RAMRIS score
 JSN 0.2 ± 0.4 0.3 ± 0.7 0.1 ± 0.3 0.347 5.9 ± 8.4 5.9 ± 8.5 0.0 ± 0.4 <1.000
 Synovitis 3.2 ± 2.1 3.1 ± 2.1 -0.1 ± 0.9 0.598 4.9 ± 2.6 3.9 ± 2.3 -l.0 ± 2.1 0.126
 Bone erosion 2.6 ± 2.2 2.6 ± 2.6 0.0 ± 0.9 <1.000 20.5 ± 33.4 21.2 ± 33.3 0.6 ± 1.2 0.171
 Bone edema 4.9 ± 4.0 4.9 ± 3.6 0.0 ± 1.1 <1.000 9.7 ± 7.8 7.1 ± 6.3 -2.6 ± 3.8 0.105
  1. MTX methotrexate, TNFa tumor necrosis factor alpha, ESR erythrocyte sedimentation rate, CRP C-reactive protein, DAS-28 disease activity score 28, HAQ health assessment questionnaire score, JSN joint space narrowing, NA not applicable, RAMRIS Outcome Measures in Rheumatology (OMERACT) rheumatoid arthritis-magnetic resonance imaging scoring. *Paired t test