Total (n = 22)
|
MTX only group (n = 9)
|
MTX + anti-TNFα group (n = 13)
|
---|
Mean ± SD
|
Baseline
|
3 Months
|
Changes
|
p value*
|
Baseline
|
3 Months
|
Changes
|
p value*
|
---|
Disease activity
|
Swollen joints
|
0.7 ± 1.0
|
1.6 ± 1.8
|
0.9 ± 1.8
|
0.184
|
14.5 ± 3.9
|
6.3 ± 4.8
|
-8.2 ± 6.6
|
<0.001
|
Tender joints
|
0.7 ± 1.1
|
1.0 ± 1.3
|
0.3 ± 1.2
|
0.438
|
9.3 ± 6.2
|
4.4 ± 9.5
|
-4.9 ± 9.9
|
0.086
|
Global assessment of patient
|
7.4 ± 15.3
|
16.3 ± 25.7
|
8.9 ± 19.6
|
0.210
|
62.2 ± 16.8
|
41.4 ± 31.2
|
-20.8 ± 26.6
|
0.015
|
Physician
|
11.7 ± 10.9
|
14.1 ± 12.6
|
2.4 ± 9.4
|
0.459
|
42.8 ± 10.7
|
26.4 ± 12.1
|
-16.4 ± 18.2
|
0.005
|
ESR unm h) (mm/h)
|
18.0 ± 22.3
|
21.0 ± I8.3
|
3.0 ± 10.9
|
0.435
|
32.2 ± 21.9
|
29.7 ± 21.6
|
-2.4 ± 12.9
|
0.490
|
CRP tmg/L) (mg/L)
|
2.1 ± 1.1
|
4.6 ± 3.5
|
2.4 ± 2.9
|
0.034
|
21.9 ± 28.1
|
10.4 ± 9.8
|
-11.5 ± 22.2
|
0.088
|
DAS-28-ESR
|
1.9 ± 0.9
|
2.6 ± 0.9
|
0.7 ± 1.2
|
0.106
|
5.7 ± 1.1
|
3.8 ± 1.2
|
-2.0 ± 0.9
|
<0.001
|
DAS-28-CRP
|
l.8 ± 0.7
|
2.4 ± 0.8
|
0.6 ± 0.6
|
0.032
|
5.4 ± 0.9
|
3.5 ± 1.0
|
-I.7 ± 1.1
|
<0.001
|
HAQ
|
0.5 ± 0.7
|
0.7 ± 0.8
|
0.2 ± 0.3
|
0.084
|
1.6 ± 0.7
|
1.0 ± 0.7
|
-0.6 ± 0.6
|
0.001
|
Modified SHARP score
|
Total
|
4.7 ± 6.0
|
NA
|
NA
| |
26.1 ± 42.0
|
NA
|
NA
| |
Erosion
|
1.6 ± 2.6
| | | |
13.5 ± 26.8
| | | |
JSN
|
3.1 ± 4.9
| | | |
12.5 ± 17.0
| | | |
RAMRIS score
|
JSN
|
0.2 ± 0.4
|
0.3 ± 0.7
|
0.1 ± 0.3
|
0.347
|
5.9 ± 8.4
|
5.9 ± 8.5
|
0.0 ± 0.4
|
<1.000
|
Synovitis
|
3.2 ± 2.1
|
3.1 ± 2.1
|
-0.1 ± 0.9
|
0.598
|
4.9 ± 2.6
|
3.9 ± 2.3
|
-l.0 ± 2.1
|
0.126
|
Bone erosion
|
2.6 ± 2.2
|
2.6 ± 2.6
|
0.0 ± 0.9
|
<1.000
|
20.5 ± 33.4
|
21.2 ± 33.3
|
0.6 ± 1.2
|
0.171
|
Bone edema
|
4.9 ± 4.0
|
4.9 ± 3.6
|
0.0 ± 1.1
|
<1.000
|
9.7 ± 7.8
|
7.1 ± 6.3
|
-2.6 ± 3.8
|
0.105
|
-
MTX methotrexate, TNFa tumor necrosis factor alpha, ESR erythrocyte sedimentation rate, CRP C-reactive protein, DAS-28 disease activity score 28, HAQ health assessment questionnaire score, JSN joint space narrowing, NA not applicable, RAMRIS Outcome Measures in Rheumatology (OMERACT) rheumatoid arthritis-magnetic resonance imaging scoring. *Paired t test