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Table 3 Comparison of erosion volume and bone parameters by high-resolution peripheral quantitative computed tomography between baseline and 3 months in each treatment group

From: Assessment of 3-month changes in bone microstructure under anti-TNFα therapy in patients with rheumatoid arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT)

Total (n = 19) MTX-only group (n = 9) MTX + anti-TNFα group (n = 13)
Mean ± SD Baseline 3 Months Changes (A) p value* Baseline 3 Months Changes (A) p value*
MCP2
 Erosion number (n) 7 7    23 23   
 Erosion volume (mm3) 6.7 ± 6.4 7.5 ± 6.4 0.9 ± 0.5 0.006 41.4 ± 65.5 37.6 ± 60.3 -3.8 ± 5.2 0.048
Joint space         
 Width (mm) 1.81 ± 0.14 1.80 ± 0.13 -0.01 ± 0.07 0.705 1.87 ± 0.20 1.80 ± 0.15 -0.07 ± 0.09 0.028
 Volume (mm3) 133.6 ± 17.3 134.6 ± 16.0 1.0 ± 5.5 0.606 125.4 ± 20.5 118.7 ± 17.0 -6.68 ± 7.08 0.001
MCH2 microarchitecture BMD (mg/cm3)
 Total 279.9 ± 34.2 277.4 ± 40.2 -6.2 ± 16.1 0.288 316.2 ± 34.7 327.8 ± 45.9 11.6 ± 33.0 0.268
 Trabecular 236.2 ± 26.9 233.6 ± 33.2 -2.6 ± 20.4 0.731 259.0 ± 25.6 266.9 ± 41.0 7.8 ± 26.8 0.353
MCP3
 Erosion number (n) 4 4    13 13   
 Erosion volume (mm3) 2.3 ± 11.5 3.1 ± 1.2 0.8 ± 0.5 0.019 21.6 ± 31.5 18.9 ± 29.0 -2.7 ± 2.5 0.014
 Joint space         
  Width (mm) 1.72 ± 0.14 1.74 ± 0.15 0.02 ± 0.05 0.226 1.83 ± 0.12 1.74 ± 0.14 -0.10 ± 0.07 0.001
  Volume (mm3) 138.9 ± 17.0 142.1 ± 20.2 3.2 ± 4.3 0.069 131.9 ± 24.1 125.6 ± 21.4 -4.3 ± 4.6 0.003
 MCH3 microarchitecture BMD (mg/cm3)         
  Total 279.9 ± 28.0 280.8 ± 25.0 1.0 ± 7.0 0.706 324.5 ± 35.7 321.8 ± 34.8 -2.7 ± 8.4 0.298
  Trabecular 238.9 ± 20.1 241.9 ± 18.1 3.0 ± 8.1 0.322 269.4 ± 26.7 267.6 ± 26.1 -1.7 ± 8.5 0.513
Distal radius
 Erosion number (n) 15 15    11 11   
 Erosion volume (mm3) 21.1 ± 26.4 23.4 ± 29.1 1.6 ± 3.3 0.075 199.9 ± 362.6 188.4 ± 331.4 -15.5 ± 31.7 0.211
 Joint space         
  Width (mm3) 2.04 ± 0.24 2.04 ± 0.18 -0.01 ± 0.12 0.981 2.09 ± 0.29 2.11 ± 0.29 0.01 ± 0.17 0.758
  Volume (mm3) 249.8 ± 29.3 261.1 ± 30.5 11.3 ± 22.3 0.197 247.5 ± 67.1 240.2 ± 71.2 -7.3 ± 25.0 0.356
 Wrist microarchitecture BMD (mg/cm3)         
  Total 272.3 ± 61.3 272.8 ± 60.3 0.6 ± 4.3 0.709 356.0 ± 58.6 354.0 ± 58.4 -2.0 ± 7.1 0.357
  Cortical 793.7 ± 82.9 792.1 ± 83.2 -1.6 ± 9.8 0.663 873.4 ± 42.7 874.9 ± 43.7 1.5 ± 9.7 0.607
  Trabecular 148.0 ± 31.0 148.6 ± 30.8 0.6 ± 2.7 0.543 174.5 ± 53.7 172.0 ± 51.2 -2.5 ± 5.1 0.115
 Cortical thickness (μm) 607.8 ± 200.4 606.7 ± 199.5 3.8 ± 21.2 0.900 824.6 ± 142.7 830.8 ± 140.8 6.2 ± 27.3 0.450
 Trabecular         
  Number 1.82 ± 0.14 1.80 ± 0.17 -0.02 ± 0.15 0.748 1.97 ± 0.45 1.94 ± 0.42 -0.03 ± 0.10 0.315
  Thickness (μm) 68.9 ± 12.6 69.9 ± 12.6 1.4 ± 5.0 0.441 72.9 ± 10.8 73.1 ± 10.2 0.2 ± 4.1 0.898
  Separation (μm) 485.7 ± 51.1 491.2 ± 60.0 5.6 ± 45.6 0.740 471.5 ± 171.7 475.1 ± 156.3 3.6 ± 34.8 0.725
  1. The distal radius joint space was measured at the radio-lunar joint. MTX methotrexate, TNFa tumor necrosis factor alpha, MCH metacarpal heads, BMD bone mineral density. *Paired t test. Bold characters mean p < 0.05