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Table 1 Demographics, analytical data, and disease-related characteristics of patients with rheumatoid arthritis and control subjects

From: Incretins in patients with rheumatoid arthritis

  Control subjects (n = 210) Patients with RA (n = 151) p Value
Age, years 58 ± 9 53 ± 11 0.000
Female sex, n (%) 148 (70) 120 (79) 0.052
Body mass index, kg/m2 28 ± 5 28 ± 5 0.78
Waist circumference, cm 92 ± 14 96 ± 13 0.015
Cardiovascular risk factors, n (%)
 Smoking 42 (20) 26 (17) 0.51
 Hypertension 58 (27) 45 (30) 0.65
 Dyslipidemia 33 (15) 54 (36) 0.000
 Diabetes 0 (0) 0 (0)
Medication
 Statins 14 (6) 43 (28) 0.000
 Antihypertensive treatment 35 (16) 45 (30) 0.003
Analytical data
 CRP, mg/dl 1.0 (1.0–3.0) 3.2 (1.5–5.8) 0.000
 ESR, mm/h 10 ± 8 34 ± 22 0.000
 Triglycerides, mg/dl 104 ± 50 144 ± 92 0.000
 HDL cholesterol, mg/dl 63 ± 18 56 ± 15 0.000
 LDL cholesterol, mg/dl 135 ± 34 121 ± 31 0.000
 Total cholesterol, mg/dl 219 ± 37 206 ± 36 0.001
 Lipoprotein A, mg/dl 16 (9–39) 35 (11–121) 0.000
 Apolipoprotein A1, mg/dl 191 ± 35 170 ± 28 0.000
 Apolipoprotein B, mg/dl 102 ± 24 110 ± 63 0.11
 ApoB/ApoA ratio 0.55 ± 0.16 0.66 ± 0.30 0.000
 Atherogenic index 3.7 ± 4.0 4.0 ± 3.6 0.10
Disease-related data
 Disease duration, years   6.6 (3.3–13.9)  
 ACPA, n (%)   89 (59)  
 Rheumatoid factor, n (%)   109 (72)  
 Erosions, n (%)   55 (36)  
 Extra-articular manifestations, n (%)   16 (11)  
 DAS28-ESR   3.7 ± 1.2  
 DAS28-CRP   2.9 ± 1.0  
 SDAI   15 (8–21)  
 CDAI   9 (5–16)  
 HAQ   0.630 (0.380–1.130)  
 Current prednisone, n (%)   57 (38)  
 Prednisone current doses, mg/day   5 (5–6)  
 NSAIDs, n (%)   69 (46)  
 DMARDs, n (%)   129 (85)  
 Methotrexate, n (%)   113 (75)  
 Biologic drugs, n (%)   35 (23)  
 Anti-TNF-α drugs, n (%)   20 (13)  
  1. Abbreviations: ACPA Anticitrullinated peptide/protein antibody, Apo Apolipoprotein, BMI Body mass index, CDAI Clinical Disease Activity Index, CRP C-reactive protein, DAS28 Disease Activity Score in 28 joints, DMARD Disease-modifying antirheumatic drug, ESR Erythrocyte sedimentation rate, HAQ Health Assessment Questionnaire, HDL High-density lipoprotein, LDL Low-density lipoprotein, NSAID Nonsteroidal anti-inflammatory drug, RA Rheumatoid arthritis, SDAI Simplified Disease Activity Index, TNF-α Tumor necrosis factor-α
  2. Current prednisone doses pertain to prednisone users only. Data are expressed as mean ± SD or median (IQR). Dichotomous variables are expressed as count and percent. p<0.05 are depicted in bold