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Table 2 Comparison of clinical findings between patients with and without IgG4-related periaortitis/periarteritis

From: Clinical features of IgG4-related periaortitis/periarteritis based on the analysis of 179 patients with IgG4-related disease: a case–control study

 

Univariate analysis

Multivariate analysis

Parameter

Periaortitis/periarteritis (+)

Periaortitis/periarteritis (–)

p value

OR (95% CI)

p value

Total

65

114

   

Onset age of IgG4-RD (median years)

69

65

0.0075

1.04 (1.00–1.08)

0.082

Sex (male/female)

53/12

78/36

0.057

  

Median number of other organ involvements

3

3

0.63

  

Allergy (+/–)

17/47

46/64

0.044

0.49 (0.23–1.05)

0.065

Smoking (+/–)

36/28

58/47

0.90

  

Hypertension (+/–)

30/34

37/70

0.11

  

Median IgG (mg/dl)

2266

1854

0.00015

1.0007 (1.0002–1.001)

0.0035

Median IgG4 (mg/dl)

511

376

0.012

  

Median IgE (IU/ml)

172

100

0.12

  

Median WBC (/μl)

6190

6090

0.87

  

Median CRP (mg/dl)

0.17

0.13

0.68

  

Median RF (U/ml)

7

6

0.73

  

Median CIC (μg/ml)

5.3

4.8

0.042

0.96 (0.88–1.04)

0.29

Median sIL-2R (U/ml)

885

659

0.00049

1.0004 (1.00–1.001)

0.23

  1. The onset age of IgG4-RD was significantly higher in the positive group. Laboratory tests revealed significant disease activity marker increases in the positive group for IgG, IgG4, CIC, and sIL2R. IgG remained significantly higher in the positive group according to multiple logistic analysis
  2. OR odds ratio, CI confidence interval, CIC circulating immune complex, CRP C-reactive protein, IgE immunoglobulin E, IgG immunoglobulin G, IgG4-RD immunoglobulin G4-related disease, RF rheumatoid factor, sIL-2R soluble interleukin-2 receptor, WBC white blood cells