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Table 2 Clinical and imaging scores at Visit 1 and Visit 2 (4 months later)

From: Changes in clinical disease activity are weakly linked to changes in MRI inflammation on treat-to-target escalation of therapy in rheumatoid arthritis

  Total (N = 84) Group A (N = 57) Group B (N = 27*) Median two-sample test p value
N Median Minimum Maximum N Median Minimum Maximum N Median Minimum Maximum
Clinical scores at Visit 1
 Tender 28 joints 84 11 1 28 57 10 1 28 27 14 1 28 0.050
 Swollen 28 joints 84 4 0 20 57 4 0 11 27 6 0 20 0.097
 HAQ 84 1.06 0 2.5 57 0.88 0 2.13 27 1.38 0.13 2.5 0.037
 DAS28CRP 84 4.5 3.24 6.64 57 4.24 3.24 6.04 27 5.15 3.36 6.64 0.003
MRI scores at Visit 1
 Synovitis 77 3 0 9 51 3 0 9 26 4 0 9 0.102
 Tendonitis 77 3 0 15 51 3 0 15 26 3 0 15 0.931
 Osteitis 77 2 0 34 51 2 0 34 26 3 0 24 0.021
 Erosion 76 5 0 50 50 4 0 50 26 9 1 47 0.030
 Total inflammation 77 9 0 45 51 8 0 45 26 13 1 36 0.050
X-ray scores at Visit 1
 Erosions 62 13 0 130 42 5.5 0 112 20 33.5 0 130 0.001
 Total SvdH score 62 35.5 0 217 42 20.5 0 217 20 63 0 209 0.031
Clinical scores at Visit 2
 Tender 28 joints 72 6 0 28 48 5 0 28 24 7 0 24 0.399
 Swollen 28 joints 72 1 0 20 48 1 0 20 24 0.5 0 9 0.337
 HAQ 72 0.63 0 2.13 48 0.5 0 2 24 0.75 0 2.13 0.155
 DAS28CRP 72 3.47 1.42 6.64 48 3.28 1.42 6.64 24 3.66 1.42 5.49 0.047
MRI scores at Visit 2
 Synovitis 66 3 0 9 42 3 0 9 24 3 0 8 0.851
 Tendonitis 66 2.5 0 15 42 2 0 15 24 3 0 12 0.612
 Osteitis 68 2 0 34 44 2 0 32 24 3.5 0 34 0.102
 Erosion 67 6 0 50 43 4 0 50 24 9.5 1 47 0.009
 Total inflammation 66 9 1 53 42 9 1 43 24 9 1 53 1.000
  1. *Includes the four patients who transitioned from Group A to Group B on escalation of therapy (see text)
  2. DAS28 CRP disease activity score (28 joints) incorporating C-reactive protein, MRI magnetic resonance imaging, SvdH Sharp van der Heijde, HAQ Health assessment questionnaire