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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response

Fig. 1

Cre LysM Casp8 flox/flox mice display accelerated resolution and Cre CD11c Casp8 flox/flox mice exhibit accelerated initiation of K/BxN serum-transfer-induced arthritis. Male Casp8 flox/flox (control, n = 15), Cre LysM Casp8 flox/flox (n = 16) and Cre CD11c Casp8 flox/flox (n = 16) mice, 10 − 12 weeks old, were intravenously injected with K/BxN serum. a Depicted are combined “change in ankle width” and “clinical score” from two individual experiments. Differences between control and Cre LysM Casp8 flox/flox or Cre CD11c Casp8 flox/flox mice are compared by two-way analysis of variance with the Bonferroni post-hoc test: *p < 0.05; **p < 0.005; ***p < 0.0005. b Day-0 and day-7 serum cytokine levels from control (n = 5), Cre LysM Casp8 flox/flox (n = 5) and Cre CD11c Casp8 flox/flox (n = 5) mice. c Day-7 ankles stained with hematoxylin and eosin (H&E). Day 7P = pannus; SL = synovial lining; C = cartilage; B = bone; BM = bone marrow. Histologic scoring of H&E-stained ankle sections from day-7 control (n = 8), Cre LysM Casp8 flox/flox (n = 10) and Cre CD11c Casp8 flox/flox (n = 10) (d, e) and day-14 control (n = 4), Cre LysM Casp8 flox/flox (n = 4) and Cre CD11c Casp8 flox/flox (n = 4) (f, g). Data are means ± SEM and differences between control and Cre LysM Casp8 flox/flox or Cre CD11c Casp8 flox/flox mice were compared by the Mann-Whitney test: *p < 0.05; ***p < 0.0005. Casp8 caspase-8, IL, interleukin, PMN polymorphonuclear cells

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